Vicinal Diaryl Substituted Heterocycles: A Gold Mine for the Discovery of Novel Therapeutic Agents

As flexible building blocks for the production of novel compounds, vicinal diaryl-substituted heterocycles are a rich source of leads for the development of new drugs. Their adaptability means that they can be used to produce structures with a broad range of attractive characteristics, and a large number of vicinal diaryl-substituted heterocyclic compounds have already been synthesized and investigated by medicinal chemists as promising lead molecules. Vicinal Diaryl-Substituted Heterocycles draws together all of the key information about these compounds in one place for the first time. Following an informative overview of the importance of these structures to the discovery of potential therapeutic agents, the text goes on to outline the main compound types, with each chapter focusing on the activities of a different structure. Designed to support researchers by consolidating this important information in a single, practical guide, the authors hope to encourage further advancement and development in the discovery of novel therapeutic agents. Collects together details of the key vicinal diaryl-substituted heterocyclic compounds in one place for the first timeHighlights biological activities and SAR of derivativesStructured practically for ease of navigation between different derivatives INDICE: 1. Importance of VDHS in the discovery of potential therapeutic agents 2. Biological activities of vicinal diaryl-substituted azetidinones 3. Biological activities of vicinal diaryl-substituted pyrroles 4. Biological activities of vicinal diaryl-substituted imidazoles 5. Biological activities of vicinal diaryl-substituted pyrazoles 6. Biological activities of vicinal diaryl-substituted triazoles and tetrazoles 7. Biological activities of vicinal diaryl-substituted furans 8. Biological activities of vicinal diaryl-substituted thiazoles, thiazolines, thiazolidinones and thiadiazoles  9. Biological activities of vicinal diaryl-substituted oxadiazoles, oxazoles and isoxazoles 10. Biological activities of vicinal diaryl-substituted other five membered heterocycles 11. Biological activities of vicinal diaryl-substituted six and seven membered heterocycles 12. Biological activities of vicinal diaryl-substituted fused heterocycles

• ISBN: 978-0-08-102237-5
• Editorial: Elsevier
• Encuadernacion: Rústica
• Páginas: 370
• Fecha Publicación: 01/04/2018
• Nº Volúmenes: 1
• Idioma: Inglés