An indispensable reference for any practicing synthetic organic or medicinal chemist, this book continues the tradition of Greene’s as comprehensive in the overall scope of coverage, providing the most relevant and useful examples to illustrate each methodology. • Presents valuable material, on the application of protective groups in organic chemistry, that is not easily found by casual searching • Helps chemists to plan, investigate, and carry out organic syntheses in an efficient manner • Adds over 2800 new references to update since the publication of the last edition • Reviews of the prior edition: An essential bible for the library or personal bookshelf of chemists performing complex synthesis. (CHOICE, May 2007) ...the most up–to–date compilation available...should be an integral part of all institutional libraries...it is also highly recommended that individuals...maintain their own copy... (Journal of Medicinal Chemistry, March 8, 2007) ...continues to be a comprehensive guide to the techniques for the formation and cleavage of protective groups. (Journal of the American Chemical Society, January 31, 2007) INDICE: Preface to the Fifth Edition Preface to the Fourth Edition Preface to the Third Edition Preface to the Second Edition Preface to the First Edition Abbreviations 1. The Role of Protective Groups in Organic Synthesis 2. Protection for the Hydroxyl Group, Including 1,2– and 1,3–Diols Ethers Esters Protection for 1,2– and 1,3–Diols 3. Protection for Phenols and Catechols Protection for Phenols Protection for Catechols Protection for 2–Hydroxybenzenethiols 4. Protection for the Carbonyl Group Acetals and Ketals Miscellaneous Derivatives Monoprotection of Dicarbonyl Compounds 5. Protection for the Carboxyl Group Esters Amides and Hydrazides 6. Protection for the Thiol Group Thioethers Thioesters Miscellaneous Derivatives 7. Protection for the Amino Group Carbamates Amides Special –NH Protective Groups Protection for Imidazoles, Pyrroles, and Indoles Protection for Amides 8. Protection for the Alkyne –CH 9. Protection for the Phosphate Group Some General Methods of Phosphate Ester Formation Removal of Protective Groups from Phosphorous Alkyl Phosphates Phosphates Cleaved by Cyclodesesterification Benzyl Phosphates Phenyl Phosphates Photochemically Cleaved Phosphate Protective Groups Amidates Miscellaneous Derivatives 10. Reactivities, Reagents, and Reactivity Charts Reactivities Reagents Reactivity Charts Index
- ISBN: 978-1-118-05748-3
- Editorial: Wiley–Blackwell
- Encuadernacion: Cartoné
- Páginas: 976
- Fecha Publicación: 24/10/2014
- Nº Volúmenes: 1
- Idioma: Inglés