G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades, great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as well as in the development of various human diseases. This volume of Progress in Molecular Biology and Translational Science reviews the recent understanding of GPCR trafficking regulators and molecular mechanisms. Written by future leaders in the pain fieldCovers a wide range of targetsContains provocative ideas about GPCR trafficking INDICE: Studying GPCR trafficking with BRET Nevin LambertArrestin-dependent and -independent mechanisms of GPCR trafficking Vsevolod V. GurevichRegulation of GPCR trafficking by molecular chaperones Denis J. DupréRegulation of GPCR trafficking by ubiquitination and other ubiquitin-like post-translational modificationsAdriano MarcheseThe complex effects of tricyclic psychotropic drugs on alpha2A adrenergic receptor trafficking Qin WangIntracellular trafficking of neuropeptide Y-Y2 receptors Karin MörlHuman calcium receptor trafficking Kausik RayInsights into serotonin receptors trafficking: cell membrane targeting and internalizationMichèle Darmon, Sana Al Awabdh, Michel-Boris Emerit and Justine Masson Rhodopsin trafficking and mistrafficking: signals, molecular components and mechanismsYoshikazu ImanishiFunctional significance of cleavable signal peptides of G protein coupled receptorsRalf SchüleinMotif-directed cell surface transport of nascent GPCRsGuangyu WuRab GTPase regulation of GPCR trafficking in pulmonary microvascular endothelial cellsGuansong WangTemperature-sensitive intracellular traffic of alpha2C-adrenergic receptorCatalin Filipeanu
- ISBN: 978-0-12-802939-8
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 300
- Fecha Publicación: 01/06/2015
- Nº Volúmenes: 1
- Idioma: Inglés