Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

Developed as a one–stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided.     Covers both basic science and applied technology / methods     Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects     Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development     Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria INDICE: Volume 1 .List of Contributors xvii .Foreword xxix .Part 1 Basic Concepts 1 .1 Contributions of Plasma Protein Binding and Membrane Transporters to Drug ]Induced Mitochondrial Toxicity 3Gavin P. McStay .2 The Role of Transporters in Drug Accumulation and Mitochondrial Toxicity 15Kathleen M. Giacomini and Huan ]Chieh Chien .3 Structure Activity Modeling of Mitochondrial Dysfunction 25Steve Enoch, Claire Mellor, and Mark Nelms .4 Mitochondria ]Targeted Cytochromes P450 Modulate Adverse Drug Metabolism and Xenobiotic Induced Toxicity 35Haider Raza, F. Peter Guengerich, and Narayan G. Avadhani .Part 2 Organ Drug Toxicity: Mitochondrial Etiology 47 .5 Mitochondrial Dysfunction in Drug ]Induced Liver Injury 49Annie Borgne ]Sanchez and Bernard Fromenty .6 Evaluating Mitotoxicity as Either a Single or Multi ]Mechanistic Insult in the Context of Hepatotoxicity 73Amy L. Ball, Laleh Kamalian, Carol E. Jolly, and Amy E. Chadwick .7 Cardiotoxicity of Drugs: Role of Mitochondria 93Zoltan V. Varga and Pal Pacher .8 Skeletal Muscle Mitochondrial Toxicity 111Eric K. Herbert, Saul R. Herbert, and Karl E. Herbert .9 Manifestations of Drug Toxicity on Mitochondria in the Nervous System 133Jochen H. M. Prehn and Irene Llorente ]Folch .10 Nephrotoxicity: Increasing Evidence for a Key Role of Mitochondrial Injury and Dysfunction and Therapeutic Implications 169Ana Belén Sanz, Maria Dolores Sanchez ]Niño, Adrian M. Ramos, and Alberto Ortiz .11 Mammalian Sperm Mitochondrial Function as Affected by Environmental Toxicants, Substances of Abuse, and Other Chemical Compounds 185Sandra Amaral, Renata S. Tavares, Sara Escada ]Rebelo, Andreia F. Silva, and João Ramalho ]Santos .Part 3 Methods to Detect Mitochondrial Toxicity: In Vitro, Ex Vivo, In Vivo, Using Cells, Animal Tissues, and Alternative Models 205 .12 Biological and Computational Techniques to Identify Mitochondrial Toxicants 207Robert B. Cameron, Craig C. Beeson, and Rick G. Schnellmann .13 The Parallel Testing of Isolated Rat Liver and Kidney Mitochondria Reveals a Calcium ]Dependent Sensitivity to Diclofenac and Ibuprofen 217Sabine Schulz, Sabine Borchard, Tamara Rieder, Carola Eberhagen, Bastian Popper, Josef Lichtmannegger, Sabine Schmitt, and Hans Zischka .14 In Vitro Methodologies to Investigate Drug ]Induced Toxicities 229Rui F. Simões, Teresa Cunha ]Oliveira, Cláudio F. Costa, Vilma A. Sardão, and Paulo J. Oliveira .15 Combined Automated Measurement of Respiratory Chain Complexes and Oxidative Stress: A First Step to an Integrated View of Cell Bioenergetics 249Marc Conti, Thierry Delvienne, and Sylvain Loric .16 Measurement of Mitochondrial Toxicity by Flow Cytometry 265Padma Kumar Narayanan and Nianyu Li .17 MitoChip: A Transcriptomics Tool for Elucidation of Mechanisms of Mitochondrial Toxicity 275Varsha G. Desai, and G. Ronald Jenkins .18 Using 3D Microtissues for Identifying Mitochondrial Liabilities 295Simon Messner, Olivier Frey, Katrin Rössger, Andy Neilson, and Jens M. Kelm .19 Toward Mitochondrial Medicine: Challenges in Rodent Modeling of Human Mitochondrial Dysfunction 305David A. Dunn, Michael H. Irwin, Walter H. Moos, Kosta Steliou, and Carl A. Pinkert .20 Measurement of Oxygen Metabolism In Vivo 315M. P. J. van Diemen, R. Ubbink, F. M. Münker, E. G. Mik, and G. J. Groeneveld .21 Detection of Mitochondrial Toxicity Using Zebrafish 323Sherine S. L. Chan and Tucker Williamson .22 MiRNA as Biomarkers of Mitochondrial Toxicity 347Terry R. Van Vleet and Prathap Kumar Mahalingaiah .23 Biomarkers of Mitochondrial Injury After Acetaminophen Overdose: Glutamate Dehydrogenase and Beyond 373Benjamin L. Woolbright and Hartmut Jaeschke .24 Acylcarnitines as Translational Biomarkers of Mitochondrial Dysfunction 383Richard D. Beger, Sudeepa Bhattacharyya, Pritmohinder S. Gill, and Laura P. James .25 Mitochondrial DNA as a Potential Translational Biomarker of Mitochondrial Dysfunction in Drug ]Induced Toxicity Studies 395Afshan N. Malik .26 Predicting Off ]Target Effects of Therapeutic Antiviral Ribonucleosides: Inhibition of Mitochondrial RNA Transcription 407Jamie J. Arnold and Craig E. Cameron .27 Imaging of Mitochondrial Toxicity in the Kidney 419Andrew M. Hall, Joana R. Martins, and Claus D. Schuh .28 Imaging Mitochondrial Membrane Potential and Inner Membrane Permeability 429Anna ]Liisa Nieminen, Venkat K. Ramshesh, and John J. Lemasters .29 Quantifying Skeletal Muscle Mitochondrial Function In Vivo by 31P Magnetic Resonance Spectroscopy 443Graham J. Kemp .  .Volume 2 .List of Contributors xiii .Foreword xxv .Part 4 Reports from the Clinic 457 .30 Statin and Fibrate ]Induced Dichotomy of Mitochondrial Function 459Viruna Neergheen, Alex Dyson, Luke Wainwright, and Iain P. Hargreaves .31 Friend or Foe: Can Mitochondrial Toxins Lead to Similar Benefits as Exercise? 475Sofia Annis, Adeel Safdar, Eduardo Biala, Ayesha Saleem, Housaiyin Li, Priya Gandhi, Zoe Fleischmann, Carmen Castaneda ]Sceppa, Jonathan L. Tilly, Dori C. Woods, and Konstantin Khrapko .32 Involvement of Mitochondrial Dysfunction on the Toxic Effects Caused by Drugs of Abuse and Addiction 487Daniel José Barbosa, João Paulo Capela, Maria de Lourdes Bastos, and Félix Carvalho .33 Drug ]Induced Mitochondrial Toxicity during Pregnancy 509Diana Luz Juárez–Flores, Ana Sandra Hernández, Laura Garcia, Mariona Guitart ]Mampel, Marc Catalan ]Garcia, Ingrid Gonzalez ]Casacuberta, Jose César Milisenda, Josep Maria Grau, Francesc Cardellach, Constanza Morén, and Glòria Garrabou .34 Mitochondrial Toxicity in Children and Adolescents Exposed to Antiretroviral Therapy 521Antoni Noguera ]Julian, Eneritz Velasco ]Arnaiz, and Clàudia Fortuny .35 Drug ]Induced Mitochondrial Cardiomyopathy and Cardiovascular Risks in Children 529Neha Bansal, Mariana Gerschenson, Tracie L. Miller, Stephen E. Sallan, Jason Czachor, Hiedy Razoky, Ashley Hill, Miriam Mestre, and Steven E. Lipshultz .36 Role of Mitochondrial Dysfunction in Linezolid ]Induced Lactic Acidosis 547Alessandro Santini, Dario Ronchi, Daniela Piga, and Alessandro Protti .37 Metformin and Lactic Acidosis 559Jean ]Daniel Lalau .38 Lessons Learned from a Phase I Clinical Trial of Mitochondrial Complex I Inhibition 563Cecilia C. Low Wang, Jeffrey L. Galinkin, and William R. Hiatt .39 Pharmacological Activation of Mitochondrial Biogenesis for the Treatment of Various Pathologies 569Whitney S. Gibbs, Natalie E. Scholpa, Craig C. Beeson, and Rick G. Schnellmann .40 Mitochondrial Toxicity Induced by Chemotherapeutic Drugs 593Luciana L. Ferreira, Ana Raquel Coelho, Paulo J. Oliveira, and Teresa Cunha ]Oliveira .Part 5 Environmental Toxicants and Mitochondria 613 .41 The Mitochondrial Exposome 615Douglas I. Walker, Kurt D. Pennell, and Dean P. Jones .42 Central Mitochondrial Signaling Mechanisms in Response to Environmental Agents: Integrated Omics for Visualization 639Young ]Mi Go, Karan Uppal, and Dean P. Jones .43 Detection of Mitochondrial Toxicity of Environmental Pollutants Using Caenorhabditis elegans 655Laura L. Maurer, Anthony L. Luz, and Joel N. Meyer .44 Persistent Organic Pollutants, Mitochondrial Dysfunction, and Metabolic Syndrome 691Hong Kyu Lee and Youngmi Kim Pak .45 Cigarette Smoke and Mitochondrial Damage 709Jalal Pourahmad, Marjan Aghvami, Mohammad Hadi Zarei, and Parvaneh Naserzadeh .Index 727

• ISBN: 978-1-119-32970-1
• Editorial: Wiley–Blackwell
• Encuadernacion: Cartoné
• Páginas: 816
• Fecha Publicación: 20/04/2018
• Nº Volúmenes: 1
• Idioma: Inglés