Now in its third edition, this classic reference is the one-stop-shop for information on the foundations of medicinal chemistry for pharmaceutical researchers who are involved in drug development and discovery but who do not have a background in medicinal chemistry. Wermuth aids pharmaceutical researchers and chemists in making faster, more accurate identifications of the active substances that could potentially treat the disorder they are researching. New chapters on Drug Absorption and Transport give pharmaceutical scientists informationon how potential drugs can move through the drug discovery/development phasesmore quickly.This third edition still stands as the only source for practicalaspects of medicinal chemistry by focusing on the daily problems met by the medicinal chemist in drug discovery. New to this edition include: focus on chemoinformatics and drug discovery; enhanced pedagogical features; new chapters including drug absorption and transport, and, multi-target drugs. It includes updates on hot new areas: drug discovery and the latest techniques; how potential drugs can move through the drug discovery/development phases more quickly; and chemoinformatics INDICE: Parte I. General aspects of medicinal chemistry. Parte II. Lead compound discovery strategies. Parte III. Primary exploration of structure activity relationships. Parte IV. Substituents and functions, qualitative and quantitative aspects of structure activity relationships. Parte V. spatial organization, receptor mapping and molecular modeling. Parte VI. Chemical modifications influencing the pharmacokinetic properties. Parte VII. Pharmaceutical and chemical means to solubility and formulation problems. Part VIII. Development of new drugs, legal and economic aspects. Index.
- ISBN: 978-0-12-374194-3
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 942
- Fecha Publicación: 28/07/2008
- Nº Volúmenes: 1
- Idioma: Inglés