Safety of nanoparticles: from manufacturing to medical applications

In spite of the potential use of nanomaterials as tissue engineering devices,implants, biosensors, drug delivery devices, etc., there has yet to be a compilation of the risks associated with the in vivo use of nanomaterials. There are numerous and well-known risks because of the size of nanoparticles. For example, nanoparticles can cross cell membranes and enter the cytoplasm undetected. The aim of this book is to provide one of the first (if not the first) detailed views of how cells and tissues in the body deal with nanoparticles. This is important not only for implantable devices, but also for the manufacturing of nanophase materials when particles can be inhaled or enter the body throughthe skin. Only by compiling research at the intersection of nanoparticles andbiological processes can we determine if nanophase materials are safe to be manufactured, handled, and/or implanted for various medical applications. Firstdetailed presentation of a key issue in nanotechnology and nanomedicine Of interest to researchers in both nanotechnology/nanomaterials and medicine Presents safety issues as an outgrowth of research into cellular responses to nanoparticles INDICE: Developing Practices for Safe Handling of Nanoparticles and Nanomaterials in a Development-Stage Enterprise.- Nanoparticle Safety.- Breeching Epithelial Barriers - Physiochemical Factors Impacting Nanomaterial Translocation and Toxicity.- Safety and Efficacy of Nano/Micro Materials.- Biomedical Applications of Nanoparticles.- Unexpected Reactions by in vivo Application of PEGylated Liposomes.- Hydrogel Nanocomposites: Biomedical Applications, Biocompatibility and Toxicity Analysis.- Cytotoxicity and Genotoxicity of Carbon Nanomaterials.- Calcium Phosphate Nanoparticles: Toxicology and Lymph Node Targetingfor Cancer Metastasis Prevention.- Nanoparticles for Cancer Diagnosis and Therapy.

• ISBN: 978-0-387-78607-0
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 310
• Fecha Publicación: 01/10/2008
• Nº Volúmenes: 1
• Idioma: Inglés