Biology and Engineering of Stem Cell Niches

Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type. Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and systemAuthored and edited by authorities in this emerging and multidisciplinary fieldIncludes valuable links to 5-10 minute YouTube© author videos per chapter that describe main points from these leaders in the field INDICE: 1. The need to study, mimic and target stem cell niches Part 1 Biology of Stem Cell Niche and Examples 2. The Basic Principles of Stem Cells and Niche 3. Stem Cell Niche: Lessons from Drosophila 4. Embryonic Stem Cell Microenvironment 5. Haematopoetic Stem Cell Niche in the Bone Marrow 6. Neuronal Stem Cell Niche 7. Cardiovascular Stem Cell Niche 8. The Intestinal Crypt Niche 9. The Hair Follicle Stem Cell Niche 10. Skeletal Muscle: The Satellite Cell Niche 11. Cancer Stem Cell Niche Part 2 Components of Stem Cell Niche in Vivo 12. Stem Cell Inducing Biochemical Factors 13. Extracellular Matrix Molecules (ECM) 14. Cell-Matrix Adhesions and Interactions 15. Cell- Cell Adhesions and Interactions Part 3 Biochemical & Physical Cues Directing Cell Fate in Vitro 16. Matrix Chemistry Controlling Stem Cell Behavior 17. Matix Growth Factors & Surface Ligands 18. Matrix Stiffness and Effects on Stem Cell Fate 19. Stem Cell Interaction with Topography 20. Matrix Degradation 21. Surface Energy and Wettability 22. Effect of Hypoxia Part 4 Designing Smart Biomaterials to Mimic & Control Stem Cell Niche 23. Bioactive Matrix Materials & Design based on ECM Biology 24. Polymer Design and Development 25. Ceramics and Glasses 26. Surface Functionalization of Biomaterials  27. Biofunctional Hydrogels for Stem Cell 3D Culture 28. Technologies to Engineer Substrate Mechanical Properties 29. Micro and Nano Surface Patterning Technologies 30. Biomimetic Nanofibers as an Artificial Stem Cell Niche 31. Self Assembling Nanostructure 32. Microfluidic Devices induced Concentration Gradients 33. Tissue Derived Matrices Part 5 Application of Biomaterials as Stem Cell Niche in Tissue Regeneration 34. Embryonic Stem Cell Cells and Niche Engineering 35. Neural Tissue Engineering 36. Cardiovascular Tissue Engineering 37. Blood Vessel Regeneration 38. Bone Tissue Engineering 39. Cartilage Tissue Engineering 40. Skeletal Muscle Tissue Engineering 41. Tooth Tissue Engineering 42. Immune Cells and Biomaterials 43. Skin / Wound Healing and Bioengineering 44. Liver Tissue Engineering 45. Renal Regeneration 46. Organs on a Chip

• ISBN: 978-0-12-802734-9
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 675
• Fecha Publicación: 01/04/2017
• Nº Volúmenes: 1
• Idioma: Inglés