Substance P: From Pain to Cancer provides a complete discussion of substance P biology, its role in normal physiology and a variety of diseases. It provides an introduction to substance P and its pharmacology, followed by exploring its role across the human body including gastrointestinal function, cardiovascular function, learning and memory, emesis, respiration and sleep. It then discusses the critical role of substance P in several disease states including brain injury, neurodegeneration, seizures, depression and anxiety, cancer, musculoskeletal disorders, and viral infection, including COVID-19. The book closes with a look towards future perspectives for substance P.Substance P in Health and Disease is the latest volume in the Molecular Mediators in Health and Disease series and is an ideal reference for researchers across the life sciences interested in understanding the role of this multi-functioning mediator and its biological significance. Provides a comprehensive overview of the role of substance P across different organ systems, including the gut, the cardiovascular system and renal functionIncludes detailed coverage of the specific actions of substance P in various disease states and conditions, such as inflammation, cancer, neurotrauma, Parkinson’s disease, Alzheimer’s disease and viral infection including COVID-19Examines substance P as a modulator of pain perceptionIncludes expertise from a range of interdisciplinary areas including molecular biology, pharmacology, physiology, neuroscience, anatomy, and therapeutics INDICE: Part I: Introduction to Substance P 1. The synthesis, release and binding of substance P 2. The anatomical distribution of substance P receptors 3. Substance P in non-mammalian biology Part II: Substance P pharmacology 4. Measurement of substance P 5. Substance P antagonists Part III: Substance P in organ function 6. Substance P in the gut 7. Substance P in the cardiovascular system 8. Substance P in the renal system and micturition 9. Substance P in learning and memory 10. Substance P in the central control of nausea and vomiting 11. Substance P in CNS reward and addition 12. Substance P in sleep 13. Substance P in the central control of respiration 14. Substance P in pain 15. Substance P in bone metabolism 16. Substance P in platelet aggregation and would healing 17. Life without substance P - the naked mole rat Part IV - Substance P in Disease 18. Substance P in inflammation 19. Substance P in oxidative stress 20. Substance P in cancer 21. Substance P in the cardiac dysfunction 22. Substance P in neurotrauma 23. Substance P in stroke 24. Substance P in concussion and CTE 25. Substance P in Parkinson’s disease and Alzheimer’s disease 26. Substance P in depression 27. Substance P in stress and anxiety 28. Substance P in seizures and epilepsy 29. Substance P in musculoskeletal disorders 30. Substance P in acupuncture 31. Substance P in cough and asthma 32. Substance P in sudden infant death syndrome (SIDS) 33. Substance P in in immunity 34. Substance P in infection (non-viral) 35. Substance P in viral infection including COVID-19 36. Substance P In pruritis 37. Substance P in alopecia 38. Controversies in clinical translation 39. Future directions and perspectives
- ISBN: 978-0-443-22194-1
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 550
- Fecha Publicación: 21/11/2024
- Nº Volúmenes: 1
- Idioma: Inglés