The Protective Arm of the Renin Angiotensin System (RAS): Functional Aspects and Therapeutic Implications

The Protective Arm of the RAS: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of the renin-angiotensin system (RAS) providing readers with early insight into a system which will become of major medical importance. It is extensively demonstrated that the RAS, when over activated, represents a disease-promoting and disease-sustaining system. But recently the protective role of the RAS has emerged supported by a large number of experimental studies. In fact, specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1-7) peptide with its receptor Mas, and the enzyme ACE 2 exert significant beneficial actions by counter-balancing the well-known harmful side of the RAS. Provides a complete understanding of the protective, beneficial role of the Renin Angiotensin System (RAS).Combines the knowledge of editors who pioneered research on protective renin angiotensin system including Dr. Robson Santos who discovered angiotensins-(1-7) and its receptor Mas; and Dr. U. Muscha Steckelings and Dr. Thomas Unger who made contributions to AT2 receptor research and were the first to use a novel specific AT2-antagonist in preclinical studies.Shows the protective RAS axes are able to ameliorate the course of several cardiovascular, renal and neurological diseases. INDICE: The Protective RAS, a new concept evolves: components and perspectives Part I: The AT2 Receptor Introduction The AT2 receptor: from enigma to therapeutic target AT2 receptor detection by selective ligands Basic mechanisms and signaling Animal models with a genetic alteration of AT2 expression AT2 signaling: resolved and unresolved AT1-AT2 crosstalk (Patho)-physiological effects of AT2R stimulation AT2R in Myocardial infarction and congestive heart failure AT2R, vascular effects, blood pressure effects                              AT2R in neuroprotection and -regeneration AT2R and cognitive function AT2R in kidney disease AT2R and natriuresis AT2R and vascular remodeling AT2R and inflammation AT2R, ATIP and cancer AT2R and sympathetic outflow Metabolic effects of AT2R stimulation Gender differences in AT2R expression and actions Future clinical application Discovery of non-peptide selective AT2R agonists Synthesis of peptide AT2 agonists Potential future clinical indications for AT2-agonists Part II: MAS Receptor / Ang(1-7) / ACE-2: Introduction The Mas Story Basic mechanisms and signaling Animal models with a genetic alteration of ACE2/MAS MAS signaling: resolved and unresolved MAS dimerisation and MAS/AT2 crosstalk Basic aspects of ACE-2 regulation and function (Patho)-physiological effects of MAS stimulation MAS in Myocardial infarction and congestive heart failure MAS, vascular effects, blood pressure effects                              MAS in neuroprotection and -regeneration MAS and cognitive function MAS in the kidney

• ISBN: 978-0-12-801364-9
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 352
• Fecha Publicación: 13/10/2015
• Nº Volúmenes: 1
• Idioma: Inglés