The Hidden World of Protein Aggregation

The Hidden World of Protein Aggregation, Volume 206 provides a comprehensive exploration of protein aggregation, uncovering the factors behind the formation of amorphous aggregates and ordered structures called amyloid fibrils. It delves into the advantages and disadvantages of protein aggregates, addressing topics such as cytotoxicity and disorders linked to misfolding. Specific chapters in this release include Protein Aggregation: An Overview, Pathways of Amyloid Fibril Formation and Aggregation, Factors Influencing Amyloid Fibril Formation, Morphological Features and Types of Aggregated Structures, Each big journey starts with a first step: Importance of Oligomerization, Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation, and more.Additional sections cover Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils, Prediction of Protein Aggregation, Amyloid Fibril Cytotoxicity and Associated Disorders, Inhibitors of Amyloid Fibril Formation, Therapeutic Approaches in Proteinopathies, Functional Amyloids, Biotechnological Applications of Amyloid Fibrils, and The Hidden World of Protein Aggregation. Provides an introduction to the folding of protein and associated conditions leading to aggregation and linked pathologyDiscusses structural biology and computational methodologies for analysis of protein (mis)folding and aggregationDescribes functional amyloids and their biotechnological applications INDICE: PrefaceBahareh Dabirmanesh and Vladimir N. Uversky1. Protein Aggregation: An OverviewVladimir N. Uversky2. Pathways of Amyloid Fibril Formation and AggregationBahareh Dabirmanesh and Fatemeh Aziziyan3. Factors Influencing Amyloid Fibril FormationKhosro Khajeh and Fatemeh Aziziyan4. Morphological Features and Types of Aggregated StructuresVladimir N. Uversky5. Each big journey starts with a first step: Importance of OligomerizationVladimir N. Uversky6. Liquid-Liquid Phase Separation as Triggering Factor of Fibril FormationVladimir N. Uversky7. Experimental Techniques for Detecting and Evaluating the Amyloid FibrilsBahareh Dabirmanesh and Farnoosh Farzam8. Prediction of Protein AggregationKhosro Khajeh9. Amyloid Fibril Cytotoxicity and Associated DisordersKhosro Khajeh10. Inhibitors of Amyloid Fibril FormationKhosro Khajeh and Fatemeh Aziziyan11. Therapeutic Approaches in ProteinopathiesVladimir N. Uversky12. Functional AmyloidsBahareh Dabirmanesh13. Biotechnological Applications of Amyloid FibrilsBahareh Dabirmanesh14. The Hidden World of Protein AggregationBahareh Dabirmanesh and Vladimir N. Uversky

• ISBN: 978-0-443-29340-5
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 528
• Fecha Publicación: 06/06/2024
• Nº Volúmenes: 1
• Idioma: Inglés