Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices. Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists. Allows readers to systematically integrate up-to-date research findings into their laboratory work Presents focused explorations of bioanalytical methods for bioavailability and bioequivalence assessment Provides clinical applications of concepts INDICE: 1. Basic principles and concept in Toxicokinetic2. Factors Influencing Drug Toxicity3. Molecular biology of apoptotic, necrotic and necroptotic cell death4. Toxicogenomic in drug safety assessment5. Understanding the concept of signal toxicity6. Importance of toxicity testing7. Methods and Models for in vitro toxicity8. New Emerging technologies for genetic toxicity testing9. Zebrafish models for toxicological screening10. Impact of ageing on the pharmacokinetics and pharmacodynamics of the drugs11. Food-Drug Interactions and their Implications on Oral Drug Bioavailability12. Drug-Drug interactions and their implications on the Pharmacokinetics of the Drugs13. Clinical Importance of Herb-Drug interaction14. Insilico methods for the prediction of drug toxicity15. Organ-on-a-chip for assessing environmental toxicants16. Toxicity and toxicokinetics consideration in product development and drug research17. Drug Toxicity and Forensic Pharmacokinetics 18. Excipient's toxicity and safety19. Pharmaceutical excipients: Special focus on Adverse drug interactions20. Emerging role of novel excipients in drug product development and their safety concerns21. Toxicity of Pharmaceutical azo dyes22. Environmental and Safety Aspects of Bionanotechnology23. Toxicological Risk assessment of medical devices24. Developmental toxicity of nanomaterials used in healthcare25. Ethical defilements in clinical research and potential roles of Institutional review board26. Toxicodynamic in Drug research
- ISBN: 978-0-323-98367-9
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 814
- Fecha Publicación: 09/02/2022
- Nº Volúmenes: 1
- Idioma: Inglés