Dosage Form Design Parameters, Volume I examines the history as well as the current state of the field within pharmaceutical sciences and concisely explains the history of dosage form design including key developments. The contents are extrapolated to include drug development issues, scale up of formulations, regulatory issues and intellectual property. It also incorporates solid state properties and polymorphism. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of dosage form design parameters within the pharmaceutical sciences industry and research, as well as chemical engineering. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists. This book provides a comprehensive examination suitable for researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, and related industries as well as advanced students in these fields. Examines the history and most recent developments in drug dosage forms for pharmaceutical sciencesFocus on physicochemical aspects, prefomulation solid state properties and polymorphismContains extensive references for further discovery and learning appropriate for advanced undergraduate and graduate students, as well as those needing a quick understanding of drug dosage design INDICE: 1. Preformulation in drug research and pharmaceutical product development2. Physicochemical aspects to be considered in Pharmaceutical Product Development3. Role of physicochemical parameters on drug absorption and their Implications in Pharmaceutical Product Development 4. Physiologic Factors Related to Drug Absorption5. Physico-chemical, pharmaceutical and biological considerations in GIT Absorption of drugs6. Influence of Drug Properties and Routes of Drug Administration on the design of controlled release systems7. Drug stability and degradation studies8. First pass metabolism considerations in Pharmaceutical Product Development9. Dissolution profile considerations during Pharmaceutical Product Development10. Drug disposition considerations in Pharmaceutical Product Development11. Protein and tissue binding: Implication on pharmacokinetic parameters 12. Preformulation studies of drug substances, proteins and peptides: Role in drug discovery and Pharmaceutical Product Development13. Role of salt selection in drug discovery and development14. Drug Complexation: Implications in drug solubilization and oral bioavailability enhancement15. Solubility and solubilization approaches in Pharmaceutical Product Development16. Rheology and its implications on performance of liquid dosage forms17. Micromeritics in Pharmaceutical Product Development18. Four stages in Pharmaceutical Product Development - Preformulation - Prototype development - Biological aspects - Scale up studies - Commercialization 19. Scale up studies in Pharmaceutical Product Development20. Manipulation of physiological processes for Pharmaceutical Product Development21. Impact of pharmaceutical product Quality on Clinical Efficacy22. Formulation additives used in Pharmaceutical Products: Emphasis on regulatory perspectives and GRAS
- ISBN: 9780128144237
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 575
- Fecha Publicación: 01/05/2018
- Nº Volúmenes: 1
- Idioma: Inglés