Ovarian carcinoma continues to be responsible for more deaths than all other gynecologic malignancies combined, due to a continued inability to achieve detection of early (rather than advanced) stage disease and the lack of effectivetumor-specific therapeutics. Ovarian carcinogenesis, invasion, and metastaticdissemination require a complex cascade of interrelated genetic, molecular, and biochemical events that regulate the neoplastic transition of normal ovarian surface epithelium. This updated second edition includes exciting new advances in ovarian cancer detection and treatment and provides an analysis of current research into aspects of malignant transformation, growth control, and metastasis. A more detailed understanding of these processes may ultimately translate into the development of novel approaches for the detection and control of ovarian cancer. INDICE: Chemoprevention of Ovarian Cancer.- Staging and Surgical Treatment.- Novel Therapeutic Targets.- Biomarker Targets and Novel Therapeutics.- Tumor Suppressor Genes.- Epigenetics and Ovarian Cancer.- Aberrant Epithelial Differentiation in Ovarian Cancer.- The Human Kallikrein Gene Family.- Soluble Epidermal Growth Factor Receptor (sEGFR).- Activated Epidermal Growth Factor Receptor in Ovarian Cancer.- Ras-Superfamily GTP-ases in Ovarian Cancer.- Lipid Generation and Signaling in Ovarian Cancer.- LPA and Invasion.- Cell Adhesion inOvarian Cancer.- Microenvironmental Regulation of Ovarian Cancer Metastasis.-Organotypic Models of Metastasis.- Animal Models of Ovarian Cancer.- Index.
- ISBN: 978-0-387-98093-5
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 435
- Fecha Publicación: 01/07/2009
- Nº Volúmenes: 1
- Idioma: Inglés