Multichain immune recognition receptor signaling: from spatiotemporal organization to human disease

This book intends to assemble reviews on the progress in defining and controlling the spatiotemporal organization of key events in immune cell activation. Improved understanding of MIRR-mediated signaling has a number of potential practical applications, from the rational design of drugs and vaccines to the engineering of cells for biotechnological purposes. In Section 1, spatial organization and physiological function of the MIRR family members such as T cell receptor (TCR), B cell receptor (BCR), Fc receptors, natural killer (NK) cell receptors, and platelet glycoprotein VI (GPVI) will be reviewed. Section 2 will focus on current models of MIRR-triggering and highlight modern technologies to visualize cell-cell interaction contacts such as immunological synapse and to measure protein-protein interactions in space in real time. Potential therapeutic strategies targeting the MIRR-mediated transmembrane signal transductionwill be shortly reviewed in Section 3. INDICE: From the contents T-Cell Receptor.- B-Cell Receptor.- Fc Receptors.- Natural Killer Cell Receptors.- Platelet Glycoprotein VI.- Clustering Models.- Segregation Models.- Kinetic Proofreading Model.- Serial Triggering Model.- Conformational Model.- Permissive Geometry Model.- Signaling Chain Homooligomerization (School) Model.- Visualization of Cell-Cell Interaction Contacts—Synapses and Kinapses.- Visualization of Protein Interactionsin Living Cells.- Immunogenicity in Peptide-Immunotherapy: From Self/Nonself to Similar/Dissimilar Sequences.- Therapeutic Application of Transmembrane T and Natural Killer Cell Receptor Peptides.- Fc Receptor Targeting in the Treatment of Allergy, Autoimmune Diseases and Cancer.- Therapeutic Blockade of T-Cell Antigen Receptor Signal Transduction and Costimulation in Autoimmune Disease.- MHC and MHC-Like Molecules: Structural Perspectiveson the Design of Molecular Vaccines.- SCHOOLModel and New Targeting Strategies.- Immune Receptor Signaling, Aging and Autoimmunity.

• ISBN: 978-0-387-09788-6
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 385
• Fecha Publicación: 01/10/2008
• Nº Volúmenes: 1
• Idioma: Inglés