Motor Neurone Disease, Volume 176 in the International Review in Neurobiology serial highlights new advances, with this new volume presenting interesting chapters written by an international board of authors. Updates include chapters on Clinical features, differential diagnosis and pathology, Recent advances in genetics of familial and sporadic ALS, Non-coding genome contribution to ALS, Contribution of neurophysiology to the diagnosis and monitoring ALS, Advances in symptom management and monitoring disease progression, Use of biomarkers in clinical trials and future developments that will help identify new biomarkers, Application of systems biology to identify therapeutic targets, and much more. Additional sections cover Evidence of mitochondrial dysfunction (in ALS) and how to measure it in model systems, Current neuroprotective therapies and future prospects, The role of glial cells in ALS, Dysregulation of RNA biology in ALS, New developments in pre-clinical models of ALS to guide translation. Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in International Review on Neurobiology seriesUpdated release includes the latest information on Motor Neuron Disease INDICE: 1. Clinical features, differential diagnosis and pathologyMichael van Es2. Recent advances in genetics of familial and sporadic ALSAmmar Al Chalabi3. Non-coding genome contribution to ALSJohn Cooper-Knock4. Contribution of neurophysiology to the diagnosis and monitoring ALSJames Alix5. Advances in symptom management and monitoring disease progressionChris McDermott6. Use of biomarkers in clinical trials and future developments that will help identify new biomarkersAndrea Malaspina7. Application of systems biology to identify therapeutic targetsJanine Kirby and Bryan Traynor8. Evidence of mitochondrial dysfunction (in ALS) and how to measure it in model systemsHeather Mortiboys and Kurt de Vos9. Current neuroprotective therapies and future prospectsPamela Shaw10. The role of glial cells in ALSRickie Patani11. Dysregulation of RNA biology in ALSGuillaume Hautbergue12. New developments in pre-clinical models of ALS to guide translationLudo van den Bosch
- ISBN: 978-0-443-14116-4
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 548
- Fecha Publicación: 30/05/2024
- Nº Volúmenes: 1
- Idioma: Inglés