Trafficking inside cells: pathways, mechanisms and regulation

The intra-cellular trafficking field has made a quantum leap in the last few decades. The three sections of this book cover the past, present and future ofthis rapidly developing field. The first section is about the compartments and pathways defined more than 50 years ago by the pioneering studies of George Palade, who received the Nobel Prize for this work. However, as shown in the chapters in this section, new approaches that allow us to study the dynamics ofthese compartments and pathways have revealed that the compartments are not as stable as was previously thought. Several issues discussed within this section are still controversial. The second section on mechanisms is what the fieldhas been focused on during the last 20-25 years. This is the largest section of the book. Starting with the work of James Rothman and Randy Schekman, components of the machinery were identified and mechanisms were deciphered. INDICE: Intracellular Compartments and Pathways: Overview.- How We Study Protein Transport.- The Golgi Apparatus.- The Endocytic Pathway.- Regulated Secretion.- Overview of Protein Trafficking Mechanisms.- Entry into the Endoplasmic Reticulum: Protein Translocation, Folding and Quality Control.- COP-Mediated Vesicle Transport.- Clathrin-Mediated Endocytosis.- Biogenesis of Dense-CoreSecretory Granules.- Lipid-Dependent Membrane Remodelling in Protein Trafficking.- Carrier Motility.- Tethering Factors.- Intracellular Membrane Fusion.- Regulation and Coordination of Intra-Cellular Trafficking: An Overview.- Regulation of Protein Trafficking by GTP-Binding Proteins.- Post-Translational Control of Protein Trafficking in the Post-Golgi Secretory and Endocytic Pathway.- Actin Doesn’t Do the Locomotion: Secretion Drives Cell Polarization.- Intracellular Trafficking and Signaling: The Role of Endocytic Rab GTPase.- The Exocytic Pathway and Development.

• ISBN: 978-0-387-93876-9
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 445
• Fecha Publicación: 01/04/2009
• Nº Volúmenes: 1
• Idioma: Inglés