Experimental investigations in the past 10-15 years have provided convincing evidence of the cancer preventive potential of berries. Berries and their components have been shown to reduce the malignant properties of cancer cells in culture by influencing genes associated with cancer development. In addition, diets containing freeze-dried berries have been shown to prevent cancer in animals, and recent data indicate that they also exhibit cancer preventive effectsin humans. 1) Describes the major groups of bioactive compounds in berries and the cancer inhibitory effects of berry extracts and individual components invitro 2) Discusses the cancer inhibitory effects of berries and berry components on tumor development in animals 3) Discusses recent results on the cancer-inhibitory effects of berries and berry components in humans INDICE: Contribution of berry anthocyanins to their chemopreventive properties.- Ursolic acid and other pentacyclic triterpenoids: Anticancer activitiesand occurrence in berries.- Biological effects of berry extracts on carcinogenic signaling pathways in vitro.- Correlation of antioxidants and antioxidant enzymes to oxygen radical scavenging activities in berries.- Chemopreventive effects of berries and berry components in animal model systems.- Berries and the prevention of esophageal adenocarcinoma.- Endothelial cell tumor preventionwith berry extracts: Clinical problems, molecular mechanisms and therapeutic opportunities.- Effects of black raspberries on UV-induced cutaneous inflammation and tumor development.- Chemopreventive effects of berries and berry components in the rodent esophagus.- Prevention of estrogen-mediated mammary tumorsin ACI rats by berries.- Inhibition of oral cancer in animal models by black raspberries and berry components.- Prevention of cancer with pomegranate and pomegranate anthocyanins.- Chemoprevention of chronic inflammatory bowel disease-induced carcinogenesis in rodent models by berries.- Prevention of oral dysplasia in humans by berry formulations.- Cancer prevention in populations high at-risk for the development of oral cancer: clinical trials with black raspberries.- Effects of black raspberries on cellular and epigenetic biomarkers of colon cancer development in humans.
- ISBN: 978-1-4419-7553-9
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 300
- Fecha Publicación: 29/11/2010
- Nº Volúmenes: 1
- Idioma: Inglés