Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart

Endocrinology of the Heart in Health and Disease covers the traditional concepts of cardio-endocrinology, the role of the various hormone systems both in health and disease, therapeutic implications, as well as other recent advances in the various fields represented. It explores how cardiac hormones are changed in various cardiac pathologies and how there has been some success in using these therapeutically. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems such as the brain, renal, and adipose. The endocrine function of the heart in both health and disease has developed a large body of research focusing on the heart both as an endocrine organ and endocrine target. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds. Endocrinology of the Heart in Health and Disease features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. The book is aimed at a wide audience including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, Cell biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology. Develops the concept of the heart as both an endocrine organ and an endocrine target, exploring the endocrine function of the heart in both health and disease Explains how the levels of several cardiac hormones are changed in various cardiac pathologies and how some hormones can be used therapeutically Offers a single resource on cardio-endocrine disease which collates and curates the wide range of advances being made in the areas of molecular biology, biochemistry, physiology, and pathology INDICE: Chapter 1: Cardiac natriuretic peptides Chapter 2: Adrenomedullin & PAMP Chapter 3: Endothelin-1 Chapter 4: Cardiokines: recent progress in elucidating the cardiac secretomeChapter 5: Novel small peptide hormones (Nesfatin, HMGB1)Chapter 6: Gut-derived hormones (e.g. GLP1, ghrelin) Chapter 7: Fat hormones, adipokines Chapter 8: Neuronal hormones and the sympathetic/parasympathetic regulation of the heart Chapter 9: Renin-angiotensin-aldosterone-System (RAAS)Chapter 10: Nuclear receptors and the adaptive response of the heart Chapter 11: Adrenergic receptorsChapter 12: Insulin signaling in the healthy and diseased heart

• ISBN: 978-0-12-803111-7
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 350
• Fecha Publicación: 01/11/2016
• Nº Volúmenes: 1
• Idioma: Inglés