Chitosan-based systems for biopharmaceuticals: delivery, targeting and polymer therapeutics

INDICE: List of Contributors xix Foreword xxv Maria Jose Alonso Preface xxvii Acknowledgments xxix Part One General Aspects of Chitosan 1 1 Chemical and Technological Advances in Chitins and Chitosans Useful for the Formulation of Biopharmaceuticals 3 Riccardo A.A. Muzzarelli 1.1 Introduction 3 1.2 Safety ofChitins and Chitosans 4 1.3 Ionic Liquids: New Solvents and Reaction Media 5 1.4 Chitin and Chitosan Nanofibrils 8 1.4.1 Mechanically Isolated Nanofibrils in the Presence of Acetic Acid 8 1.4.2 Nanochitosan Obtained from Partially Deacetylated Chitin or Deacetylated Nanochitin 9 1.5 Electrospun Nanofibers 10 1.6 Polyelectrolyte Complexes and Mucoadhesion 12 1.6.1 Chitosan Polyelectrolyte Complexes Soluble in Alkaline Medium 14 1.6.2 Polyelectrolyte Complexes of Regioselectively Oxidized Chitin 15 1.6.3 Polyelectrolyte Complexes of Chitosanwith Bacterial Cell Wall Components 15 1.7 Conclusions and Future Perspectives 16 Acknowledgments 16 References 16 2 Physical Properties of Chitosan and Derivatives in Sol and Gel States 23 Marguerite Rinaudo 2.1 Introduction 23 2.2 Chitin 24 2.2.1 Solid State of Chitin 24 2.2.2 Solubility of Chitin 24 2.2.3 Characterization of Chitin 26 2.2.4 Processing of Chitin Solution and Physical Properties of Materials 28 2.3 Chitosan 28 2.3.1 Solubility of Chitosan 28 2.3.2 Characterization of Chitosan 29 2.3.3 Processing of Chitosan-Based Materials 31 2.3.4 Complex Materials Based on Interacting Chitosan and Chitosan Derivatives 31 2.4 Conclusions and Future Perspectives 36 References 36 3 AbsorptionPromotion Properties of Chitosan and Derivatives 45 Akira Yamamoto 3.1 Introduction 45 3.2 Effect of Chitosan on the Intestinal Absorption of Poorly Absorbable Drugs 47 3.3 Effect of Chitosan Derivatives on the Intestinal Absorption of Poorly Absorbable Drugs 47 3.4 Effect of Chitosan Oligomers on the Intestinal Absorption of Poorly Absorbable Drugs 48 3.5 Colon-Specific Delivery of Insulin Using Chitosan Capsules 51 3.6 Conclusions and Future Perspectives 54 References 54 4 Biocompatibility and Biodegradation of Chitosan and Derivatives 57 Ahmad Sukari Halim, Lim Chin Keong, Ismail Zainol, and Ahmad Hazri Abdul Rashid 4.1 Introduction 57 4.2 Biocompatibility Evaluation of Chitosan and Derivatives 58 4.2.1 In Vitro Biocompatibility 60 4.2.1.1 Cytocompatibility 60 4.2.1.2 Hemocompatibility 61 4.2.1.3 Genocompatibility 62 4.2.2 In Vivo Biocompatibility 63 4.2.3 Effect of Sterilization on Biocompatibility 64 4.3 Biodegradation of Chitosan and Derivatives 65 4.3.1 Factors Influencing the Biodegradationof Chitosan and Derivatives 67 4.3.2 In Vitro Biodegradation of Chitosan and Derivatives 68 4.3.3 In Vivo Biodegradation of Chitosan and Derivatives 69 4.4Conclusions and Future Perspectives 69 References 70 5 Biological and Pharmacological Activity of Chitosan and Derivatives 75 Teresa Cunha, Branca Teixeira, Barbara Santos, Marlene Almeida, Gustavo Dias, and Jose das Neves 5.1 Introduction 75 5.2 Biological Activity 76 5.2.1 Anti

• ISBN: 978-0-470-97832-0
• Editorial: John Wiley & Sons
• Encuadernacion: Cartoné
• Páginas: 600
• Fecha Publicación: 10/02/2012
• Nº Volúmenes: 1
• Idioma: Inglés