Acetaminophen Toxicity: Experimental and Clinical Advances

Acetaminophen Toxicity: Experimental and Clinical Advances provides detailed information on the risks of consuming acetaminophen in various scenarios and effective treatments of toxicity. Divided into two parts, the foundational aspects of the book cover the mechanism of toxicity in a detailed manner, beginning with the history of acetaminophen and then delving into newly explored areas of genetics, proteomics, and metabolomics. The second half discusses clinical practices and examines where further research and therapeutic approaches may be headed. This part answers key questions about who to treat, what are the exceptions, how long do you treat, how much antidote do you need, when are other treatments necessary, and what are those other treatments. With contributions from experts in the field, the book is a thorough, well-researched, and a valuable reference for scientists, researchers, and clinicians engaged in pursuing better and more accurate diagnosis and treatment of patients with of acetaminophen toxicity. Includes comprehensive coverage of the pharmacological mechanisms of toxicityProvides risk analysis regardless of patient presentation or timing of ingestion or amount with algorithmic supportDiscusses how to determine level of toxicity and need for liver transplant with algorithmic supportOutlines new therapeutic approaches INDICE: Part 1: Foundational Aspects 1. History of Acetaminophen 2. Intracellular Signaling Mechanisms of Cell Death. 3. Mode of Cell Death 4. Inflammation 5. Regeneration 6. Biomarkers 7. Emerging Mechanisms 8. Renal Toxicity 9. Pulmonary Toxicity 10. Genomics, Proteomics and Metabolomics Part II: Clinical and Therapeutic 11. N-Acetylcysteine (NAC) 12. Adducts 13. Pre-Hospital and Poison Center Care of Overdose and Potential Overdoses Patients 14. Acetaminophen and Co-Ingestions 15. Current Standard of Care and New Developments 16. Pharmacokinetics 17. Risk Analysis and Acetylcysteine Treatment Protocols 18. Fomepizole 19. Epidemiology NPDS (Poison Center Data) CDC and Other Databases 20. Emerging Treatments 21. Liver Transplantation

• ISBN: 978-0-443-15877-3
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 400
• Fecha Publicación: 01/11/2024
• Nº Volúmenes: 1
• Idioma: Inglés