GWAS: The Rise of Hypothesis-Free Biomedical Science

GWAS: The Rise of Hypothesis-Free Biomedical Science: How Genome-Wide Association Studies (GWAS) Apply Novel Technologies to Explain Human Diseases and Transform Medicine focuses on the ideas that surround genome wide association studies. Starting with the Human Genome Project in 2000, this book discusses how GWAS are finding the genes that underlie diseases by applying novel technologies and hypothesis-free science. Every new piece of information or technology has reshaped and changed the ideas addressed, leading to improved studies. In addition, the book also tracks down how results were generated and gathered, and the unique picture they are generating in our understanding of the genetic basis of human disease The central theme of the book focuses on the development of ideas starting from The Human Genome Project in 2000, as they continually reshape in response to the results obtained through the application of GWAS on real data. While short, this book will guide readers through the turbulent and exciting history that has transformed biomedical science from the inside out. Offers a knowledgeable review of the field in a longitudinal way, focusing on how to map a genes' underlying diseases using novel technologies Presents key additional information, discoveries, and technological progress, year-by-year, starting from The Human Genome Project in 2000Offers the greatest possible understanding of GWAS' history and development in a concise formatProvides the minimum essential technical knowledge that is necessary to understand the ideas behind GWAS INDICE: Chapter 1: Genome-Wide Association Studies (GWAS): a Novel, Hypothesis-Free Approach to Biomedical ResearchChapter 2: Elementary Concepts in Human Genetics and Biomedicine Required to Understand the Idea of GWASChapter 3: Human Genetic Variation and its Role in Human DiseaseChapter 4: The Human Genome Project and its Implications for Future Biomedical ResearchChapter 5: Genetic Structure of Human Populations and the HapMap ProjectChapter 6: Predicting Genetic Architecture of Human Complex Traits and Common DiseasesChapter 7: Developing Large Biobanks and Rethinking Ethical Aspects of Human Genetic ResearchChapter 8: The First, Unsuccessful Wave of GWAS based on STR Marker ScreensChapter 9: Turning to Industry for Help: the Emergence of Affymetrix, Inc. and Illumina, Inc.Chapter 10: The Promise of GWAS is Fulfilled: the Brave New World StudyChapter 11: The Second, Successful Wave of GWAS based on SNP Marker ScreensChapter 12: Forming Massive International Collaborations to Increase Power of GWASChapter 13: Assigning Biomedical Role to Human Genes: An Explosion of Technology-Driven Knowledge DiscoveryChapter 14: Increasing Resolution: Exome Sequence and Whole-Genome SequenceChapter 15: Why is the Missing Heritability Still Missing?Chapter 16: The Emergence of Multiple -omics Universes and Limits to Hypothesis-Free ScienceChapter 17: The Future of GWAS: a Vision of Personalized Medicine - for Everyone

• ISBN: 978-0-12-801815-6
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 304
• Fecha Publicación: 01/08/2016
• Nº Volúmenes: 1
• Idioma: Inglés