This state-of-the-art book presents the forefront in the science and clinicalmanagement of myeloma bone disease. ; Assembling the work of the world's ;premier thought leaders, this book begins with sections on clinical presentation,imaging, and biochemical markers and then goes on to discuss radiation, surgical, and medical therapies. ; Specific chapters are devoted to bisphosphonatesand novel therapeutic agents, such as RANKL inhibitors, Wnt signaling inhibitors, and IMiDs. ; The mechanisms of osteoclast activation and osteoblast suppression in multiple myeloma are also explored.Myeloma Bone Disease is a valuable resource for medical, surgical, and radiation oncologists and cancer researchers. ;. INDICE: 1. Clinical presentation of myeloma bone disease (MBD) .2. Imagingof myeloma bone disease .3. Bone Markers in MBD .4. Radiation therapy for MBD.5. Surgical treatment (kyphoplasty, vertebroplasty and standard surgery) .6. Pathophysiology of MBD.7. Osteoclast activation in MBD.8. Osteoblast Suppression in MBD.9. Animal models of MBD.10. Bisphopsphonate treatment of MBD.11. Osteonecrosis of the jaw in myeloma.12. Novel therapies for MBD (Denosumab, velcade and imids).
- ISBN: 978-1-61779-688-3
- Editorial: Humana
- Encuadernacion: Rústica
- Fecha Publicación: 01/07/2012
- Nº Volúmenes: 1
- Idioma: Inglés