Monoclonal antibody and peptide-targeted radiotherapy of cancer

This book constitutes an expert discussion of the diverse aspects of monoclonal antibody and peptide-targeted radiotherapy of cancer. The chapters cover topics ranging from the optimization of design of biomolecules and radiochemistry, cell and animal models for preclinical evaluation, discoveries from key clinical trials, radiation biology and dosimetry, considerations in regulatory approval, as well as health economics issues that need to be appreciated to ultimately see their widespread use in clinical oncology. New and emerging areas such as molecular imaging in evaluating the response and resistance to targetedradiotherapy, a discussion of the bystander effect which may enhance its effectiveness, and the potential of combining cytolytic virus therapy with targeted radiotherapy have also been included. Many chapters are authored by internationally reknowned experts who have made the seminal discoveries in the field and by others who are leaders in areas that will be important to its future.

• ISBN: 978-0-470-24372-5
• Editorial: John Wiley & Sons
• Encuadernacion: Cartoné
• Páginas: 656
• Fecha Publicación: 30/07/2010
• Nº Volúmenes: 1
• Idioma: Inglés