Prodrugs and targeted delivery: towards better ADME properties

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integratedapproach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development INDICE: I PRODRUG DESIGN AND INTELLECTUAL PROPERTY Prodrug strategies in drug design The molecular design of prodrugs by functional group Increasing lipophilicity for oral drug delivery II PRODRUGS ADDRESSING ADMET ISSUES Modulating solubility through prodrugs for oral and IV drug delivery Topical and transdermal delivery using prodrugs: mechanism of enhancement Ocular delivery usingprodrugs Prodrugs designed to target transporters for oral drug delivery Enzyme-activated prodrug strategies for site-selective drug delivery Reducing Pre-systemic Drug Metabolism III CODRUGS AND SOFT DRUGS Prodrug approaches for central nervous system delivery Soft drugs Improving the use of drug combinationsthrough the codrug approach The impact of pharmacogenetics on the clinical outcomes of prodrugs IV PRECLINICAL AND CLINICAL CONSIDERATION FOR PRODRUGS Intellectual Property Primer on Pharmaceutical Patents with a Special Emphasis on Prodrugs and Metabolites Pharmacokinetic and biopharmaceutical considerations in prodrug discovery and development Directed enzyme prodrug therapies

• ISBN: 978-3-527-32603-7
• Editorial: Wiley-VCH
• Encuadernacion: Cartoné
• Páginas: 520
• Fecha Publicación: 15/12/2010
• Nº Volúmenes: 1
• Idioma: Inglés