Immunological Tolerance and Accommodation provides the latest understanding of the cellular, molecular, and systematic regulation of immunological tolerance, an area that is of fundamental importance in immunology. For one hundred years, immunologists have struggled to understand how the immune system can attack with vigor and destroy foreign cells, microorganisms, and substances, all while sparing the immune individual from inadvertent injury. Research in various fields of immunology has revealed molecular, cellular, and systemic means by which tolerance and accommodation develop, but no line of research, review article, or published volume has coordinated the various findings and theories that have emerged. This book provides the only comprehensive and unified consideration on immunological tolerance and accommodation. Provides the only presentation that integrates molecular, cellular, and systemic mechanismsEffectively coordinates both basic and clinical subjectsAddresses both tolerance and accommodation, providing the best available resource for understanding how autoimmunity and autoimmune diseases are averted in most individuals Comprehensive and unified consideration of both tolerance and accommodation INDICE: 1. Horror autotoxicus - A. the role of tolerance and accomodation in immunity. B. Definitions. C. Implications for health and diseases 2. Immunologic recognition and tolerance (structural tolerance) 3. Molecular mechanisms of tolerance (conditional tolerance) 4. Systemic tolerance 5. Molecular and cellular mechanisms of accommodation 6. When tolerance fails - autoimmunity and autoimmune diseases that ensue in relation to failure of specific mechanisms 7. Too much tolerance and accommodation - how tolerance and accommodation explain progression of cancer and persistence of infection
- ISBN: 978-0-12-407195-7
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Fecha Publicación: 01/11/2016
- Nº Volúmenes: 1
- Idioma: Inglés