Cellular Lipid in Health and Disease presents a comprehensive and systematic coverage of the various roles lipids play in human biology. This book is organized around the key roles lipids play in cellular biology, both in health and disease states. The first group of chapters is dedicated to the basic concepts of cellular lipids and the roles it plays in the cell, structure and physiology, storage, and utilization. The next set of chapters is focused on lipid metabolism, covering the organelles involved in lipid trafficking, cholesterol homeostasis, autophagy signaling, and metabolism in aging. The final group of chapters is dedicated to roles lipids play in specific disease states including diabetes, chronic kidney disease complications, obesity, heart diseases, nonalcoholic fatty liver disease, colorectal cancer, neurodegenerative diseases, B cell immunity, inflammation, viral infections, and other metabolic diseases. Cellular Lipid in Health and Disease is a complete reference targeted at graduate students and early career researchers in cell biology, biochemistry, and pharmacology. Research physicians can also benefit from the foundational content and links to pathologies and therapeutic opportunities. Offers a complete and systematic coverage of lipid biologyProvides foundational content and establishes the needed connections to translational aspects of the research in this areaIncludes chapters on the therapeutic opportunities presented by lipids INDICE: 1 Structure and function of mammalian sphingolipids in health and diseaseMariona Rabionet, Robert Engel and Roger Sandhoff2 Intracellular lipid storage and utilization in adipocytesVishva M. Sharma, James M. Ntambi and Vishwajeet Puri3 Metabolic control by lipid droplet proteinsDilip Menon, Rakesh Mohan Jha, Arpita Nahak and Sheetal Gandotra4 From endoplasmic reticulum to nucleus: the fate of cellular fatty acidsAntoine Jutras-Carignan, Tania Guillemette and Catherine Mounier5 Lipid trafficking and signaling in adipocytesYan Tang and Qi-Qun Tang6 Cell and molecular basis for maintenance of cholesterol homeostasisTownsend A. Smith and Russell A. DeBose-Boyd7 Interplay between phospholipid signaling and autophagyMeenu Maan and Mainak Dutta8 The role of cellular lipid metabolism in agingXiaoli Chen and Jun Liu9 Plasma lipid trafficking in type 2 diabetesIsabella James, Gina Wade, Helaina Von Bank, Ayren McGahee, Autumn Chevalier, Paula Gonzalez, Kayla Bote, James M. Ntambi and Judith Simcox10 Lipotoxicity in the pathogenesis of chronic kidney disease complicationsMasashi Masuda, Yuji Shiozaki and Makoto Miyazaki11 Cellular lipids in the molecular pathogenesis of obesityMashudu G. Matumba, Ademola O. Ayeleso, James M. Ntambi and Emmanuel Mukwevho12 Effects of cellular lipids on heart in pathology and physiologyVolodymyr V. Balatskyi, Marcin Wolosiewicz, Aneta M. Dobosz, Zuzanna Tracz-Gaszewska, Adrian Sowka, Maria Kendziorek, Ewelina Krogulec, Viktor O. Navrulin and Pawel Dobrzyn13 Uncoupling of fat deposition and inflammation during nonalcoholic fatty liver diseaseHonggui Li, Xinlei Guo, Eduardo Aquino and Chaodong Wu14 Cellular lipids and colorectal cancerSeong-Ho Lee and Joseph LoBianco15 Lipid metabolism in neurodegenerative diseasesJeroen F.J. Bogie, Jeroen Guns and Sam Vanherle16 Cellular lipids in B cell immunity, inflammation, and cancerYana Zhang, James M. Ntambi and Deyu Fang17 Role of cellular fatty acids in combating the corona virusAbhishek Saxena and Archana Tiwari18 Cellular lipids and viral infectionZ. Zhang, C. Baguley, X. Wang and B. Kopek19 Acetyl-CoA and acetylation in biology and diseaseLuigi Puglielli, Michael J. Rigby and Gonzalo Fernandez-Fuente20 Role of omega-3 and -6 fatty acids in the inflammatory processes of obesity, hypertension, and autoimmunityF. Enrique Go´mez, Martha Kaufer-Horwitz, He´ctor Bourges and Gabriela E. Mancera-Chavez
- ISBN: 978-0-443-21822-4
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 556
- Fecha Publicación: 03/08/2023
- Nº Volúmenes: 1
- Idioma: Inglés