Biomechanics and Mechanobiology of the Lumbar Spine: Computational Approaches: From Research to In Silico Medicine

Biomechanics and Mechanobiology of the Lumbar Spine: Computational Approaches: From Research to In Silico Medicine aims to outline how major decision points-such as goal-adapted numerical approximations-infer in the capability of lumbar spine models to provide valuable cause-and-effect relationships in the study of organ conditions and treatments. The spine presents an astonishing balance between mechanical resistance and flexibility in the human body, provided by complex interactions that are extremely difficult to restore when altered in disease. Given that these interactions are difficult to assess in situ, designing efficient treatments for low back pain remains a grand challenge in medicine. Numerical methods can greatly help to acquire educated views on the transfer of mechanical loads among spine tissues, in relation to both the biological maintenance and the pathogenesis of the organ. Along more than 10 years of activity in research, the author has explored in depth the capability of finite element models to capture the functional load transfers within the lumbar spine. Readers are expected to identify useful guidelines for model developments in both research and clinical applications. Offers an overview of modelling approaches for the development of lumbar spine finite element models towards different types of applicationsEvaluates methods based on both commonly accepted and the most advanced modelling solutionsUniquely links simulation techniques and practical knowledge about the functional biomechanics of the lumbar spineOutlines how major decision points-such as goal-adapted numerical approximations-infer in the capability of lumbar spine models to provide valuable insight for organ conditions and treatments INDICE: 1. Introduction to the lumbar spine biomechanics and mechanobiology2. Approximations in lumbar spine modelling3. Applying lumbar spine modelling to applied and basic research4. Conclusion

• ISBN: 978-1-78548-089-8
• Editorial: ISTE Press - Elsevier
• Encuadernacion: Cartoné
• Páginas: 256
• Fecha Publicación: 01/06/2016
• Nº Volúmenes: 1
• Idioma: Inglés