Proteins and peptides: pharmacokinetic, pharmacodynamic, and metabolic outcomes

A vital book that includes the lastest innovations for protein and peptide delivery. It provides clear expert guidance by scientists who freaquently naviagte the maze of protein and peptide pharmacokinetics, pharmacodynamics and metabolism. The book develops upon industry experience, by providing lessons learned on the major marketed areas to help readers anticipate and prevent potential pitfalls. ÍNDICE: 1. Overview of Pharmacokinetics and Pharmacodynamics Issues for Protein and Peptide Therapeutics. 2. Metabolic Processes Affecting Protein and Peptide Therapeutics. 3. Protein and Peptide Actions and Interactions that Alter their Pharmacokinetics, Pharmacodynamics and Metabolism. 4. Inter-Species Aspects of Pharmacokinetics, Pharmacodynamics and Metabolism Measurement. 5. In Vitro/ In Vivo Correlations of Pharmacokinetics, Pharmacodynamics and Metabolism for Cytokines. 6. In Vitro/ In Vivo Correlations of Pharmacokinetics, Pharmacodynamics and Metabolism for Extracellular Matrix-binding Growth Factors. 7.In Vitro/ In Vivo Correlations of Pharmacokinetics, Pharmacodynamics and Metabolism for Hematologic Growth Factors. 8. In Vitro/ In Vivo Correlations of Pharmacokinetics, Pharmacodynamics and Metabolism for Antibody Therapeutics. 9. Engineering as a Means to Alter the Pharmacokinetics, Pharmacodynamics and Metabolism of Injected Protein and Peptide Therapeutics Peptides. 10. Local Tissue Responses to Polymer Implants Affecting Pharmacokinetics, Pharmacodynamics and Metabolism of Proteins and Peptides. 11. Ophthalmic Delivery of Protein andPeptide Therapeutics; Pharmacokinetics, Pharmacodynamics and Metabolism Considerations. 12. Pulmonary Delivery of Protein and Peptide Therapeutics; PK/PD Considerations. 13. Oral Delivery of Protein and Peptide Therapeutics; PK/PD considerations. 14. Transdermal and Intradermal Delivery of Protein and Peptide Therapeutics; PK/PD considerations. 15. Intranasal Delivery of Protein and Peptide Therapeutics; PK/PD Considerations. 16. Considerations for Protein and Peptide Therapeutics and the Elderly. 17. Intersection of Pharmacogenetics with Pharmacokinetics and Pharmacodynamics.

• ISBN: 978-1-4200-7806-0
• Editorial: Informa Healthcare
• Encuadernacion: Cartoné
• Páginas: 280
• Fecha Publicación: 01/10/2009
• Nº Volúmenes: 1
• Idioma: Inglés