Handbook of Neurodegenerative Disorders: Mechanistic, Diagnostic and Therapeutic Advances

Handbook of Neurodegenerative Disorders: Mechanism, Diagnostic and Therapeutic Advances provides a comprehensive review on the current biomedical studies aimed at identifying the underlying causes of neurodegeneration. This book reviews the most recent developments in molecular and cellular processes altered during neurodegeneration. Divided into four parts, the first covers the mechanism of cell death in neurodegeneration. The second section reviews the recent progress in gene and gene products in neurodegeneration, including Huntington's disease, Parkinson's disease, Friedreich' s ataxia, and spinal muscular atrophy. The final sections cover the current and future diagnostic techniques of neurodegenerative disorders along with therapeutic approaches. Reviews big data and neurodegeneration disorders, including gene mappingExamines the structural basis of protein assembly into amyloid filaments in neurodegenerative diseaseCovers the progress and challenges of pharmacotherapy of neurodegenerative disorders INDICE: Part-I: Mechanism of cell death in neurodegeneration1. Pathways in AD2. Shared signalling pathways in Alzheimer’s and metabolic disease3. Abeta pathology in AD and its potential to seed and propagate4. Single-cell approaches to identify shared and distinct signatures across neurodegenerative diseases5. Modelling of neurodegenerative disease using brain organoids6. The structural basis of protein assembly into amyloid filaments in neurodegenerative disease-Benjamin7. Blood brain barrier in neurodegenerative disorders8. Protein misfolding in neurodegeneration9. Neuroinflammation and neurodegeneration10. Gut-Brain Axis in neurodegeneration11. Modelling Neural Circuits in Parkinson’s Disease12. Neuropathology of Parkinsonism in Alzheimer’s Disease13. Huntington Disease updates14. Neuroinflammation in neurodegenerationPart-II: Gene and gene products in neurodegeneration15. Big data and neurodegeneration disorders16. Genomics and PD17. RNA Binding Proteins and the Genesis of Neurodegenerative Diseases-Ahmed Moustafa, Egypt18. Molecular Genetics of Huntington’s Disease19. neuronopathic LSDs: opportunities and challenges20. Nutrigenomics and PD21. Genes and MS: updates22. Genetic mapping and big data in ALSPart-III: Present and future diagnostic approaches of neurodegenerative disorders23. Biomarkers in AD24. Biomarkers of PD25. HMGB complex in PD diagnosis26. Psychological assessment of PD patientsPart-IV: Present and future therapeutics of neurodegenerative disorders27. Pharmacotherapy of neurodegenerative disorders: challenges and hopes28. Advanced Drug Delivery Nanosystems: Perspectives and Regulatory Issues29. Towards the Development of a Device to Improve the Gait of Patients Suffering from Parkinson’s Disease30. Developing Antisense Therapies for Neurodegenerative Diseases31. Advances in Gene Therapies for the CNS32. Nutrition and PD33. Stem cell therapy in NDG disorders

• ISBN: 978-0-443-15702-8
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 550
• Fecha Publicación: 26/08/2024
• Nº Volúmenes: 1
• Idioma: Inglés