Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C?H Bonds

This thesis reports the latest developments in the direct amination of various C?H bonds using an H?Zn exchange/electrophilic amination strategy.  McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines.

The material outlined in this book shows how McDonald achieved C?H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst and O-benzoylhydroxylamines as the electrophilic nitrogen source.

McDonald’s findings are of relevance to medicinal chemistry, drug discovery and materials science. Her thesis is a source of inspiration for scientists entering the field and students beginning their PhD in a related area. 

• ISBN: 978-3-319-38877-9
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 144
• Fecha Publicación: 26/08/2016
• Nº Volúmenes: 1
• Idioma: Inglés