Integrated bioinformatics solutions have become increasingly valuable in pastyears, as technological advances have allowed researchers to consider the potential of omics for clinical diagnosis, prognosis, and therapeutic purposes, and as the costs of such techniques have begun to lessen. In Bioinformatics Methods in Clinical Research, experts examine the latest developments impacting clinical omics, and describe in great detail the algorithms that are currently used in publicly available software tools. Chapters discuss statistics, algorithms, automated methods of data retrieval, and experimental consideration in genomics, transcriptomics, proteomics, and metabolomics. Composed in the highlysuccessful Methods in Molecular Biology™ series format, each chapter containsa brief introduction, provides practical examples illustrating methods, results, and conclusions from data mining strategies wherever possible, and includes a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Informative and ground-breaking, Bioinformatics Methods in Clinical Research establishes a much-needed bridge between theory and practice, making it an indispensable resource for bioinformatics researchers. INDICE: Introduction to omics.- Machine learning: an indispensable tool inbioinformatics.- SNP-PHAGE – High throughput SNP discovery pipeline.- R classes and methods for SNP array data.- Overview on techniques in cluster analysis.- Non Alcoholic Steatohepatitis, Animal Models, and Biomarkers, What is new?.- Biomarkers in breast cancer.- Genome-wide proximal promoter analysis and interpretation.- Proteomics facing the combinatorial problem.- Methods and algorithms for relative quantitative proteomics by mass spectrometry.- Feature selection and machine learning with mass spectrometry data.- Computational Methods For Analysis of Two-Dimensional Gels.- Mass spectrometry in epigenetic research.- Computational Approaches to Metabolomics.- Algorithms and methods for correlating experimental results with annotation databases.- Analysis of biological processes and diseases using text mining approaches.
- ISBN: 978-1-60327-193-6
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 322
- Fecha Publicación: 01/11/2009
- Nº Volúmenes: 1
- Idioma: Inglés