Ricin and shiga toxins: pathogenesis, immunity, vaccines and therapeutics

In May of 2011, Western Europe experienced a severe outbreak of Shiga toxin (Stx)-producing E. coli (STEC) that culminated in more than 3200 cases and 39 deaths. While Stx is not the only virulence factor associated with STEC, it iscertainly the primary determinant associated with the onset of hemolytic uremic syndrome (HUS). At the present time, there are no clinically approved measures to neutralize Stx in individuals suffering from STEC infection. Nor are there any preventatives or therapeutics for ricin toxin. Although incidents of ricin exposure are largely unheard of, federal agencies and public health officials consider it a significant threat. It is well documented that domesticand international terrorist groups have stockpiled, and in some cases weaponized ricin with the intent of releasing it into the public sphere and causing panic, illness and/or death on a local, regional, or possibly national scale. The chapters, written by leading experts in the field, are organized so as to cover all aspects of ricin and Stx, including pathogenesis, immunity, vaccinesand therapeutics. This outstanding collection of reviews will serve as an important and readily accessible resource for the research community in the coming years. . . INDICE: Preface. Interaction of ricin and Stx with ribosomes and the sarcin-ricin loop. How ricin and Stx enter and intoxicate mammalian cells. Cellularstress response to Stx-ricin. Ricin and Stx-Inflammation. Pathogenesis of shiga-toxin producing E.coli. Ricin and Stx-Interactions with the epithelium and intestinal mucosa. Stx Pathogenesis-Kidney complications and renal failure. Toxin-induced Apoptosis. Small Molecule Inhibitors of Ricin and STX. Antibody-mediated immunity to ricin. Stx-animal models and immunotherapies. Ricin- animalmodels and immunotherapies. Ricin Vaccine Development. Subject Index

• ISBN: 978-3-642-27469-5
• Editorial: Springer Berlin Heidelberg
• Encuadernacion: Cartoné
• Páginas: 276
• Fecha Publicación: 31/01/2012
• Nº Volúmenes: 1
• Idioma: Inglés