Telomerases: chemistry, biology and clinical applications

This book isa comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basicstructure, mechanisms, and diversity of the essential and regulatory subunitsof telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed. INDICE: PrefaceChapter 1 The Telomerase Complex: An OverviewJohanna Mancini and Chantal AutexierChapter 2 Telomerase RNA: Structure, Function and Molecular Mechanisms Yehudi Tzfati and Julian J.-L. ChenChapter 3 TERT Structure, Function and Molecular MechanismsEmmanuel Skordalakes and Neal F. LueChapter 4 Telomerase Biogenesis: RNA Processing, Trafficking and Protein Interactions Tara Beattie and Pascal ChartrandChapter 5 Transcriptional Regulation of Human TelomeraseAntonella Farsetti and Yu-Sheng CongChapter 6 Telomerase Regulation and Telomere Length HomeostasisJoachim Lingner and David ShoreChapter 7 TelomereStructure in Telomerase RegulationMomchil D. Vodenicharov and Raymund J. WellingerChapter 8 Off-Telomere Functions of TelomeraseKenkichi Masutomi and William C. HahnChapter 9 Murine Models of Dysfunctional Telomeres and TelomeraseYieLiu and Lea HarringtonChapter 10 Cellular Senescence, Telomerase, and Cancer in Human Cells Phillip G. Smiraldo, Jun Tang, Jerry W. Shay, and Woodring E. WrightChapter 11 Telomerase, Retrotransposons and EvolutionIrina R. Arkhipova

• ISBN: 978-0-470-59204-5
• Editorial: John Wiley & Sons
• Encuadernacion: Cartoné
• Páginas: 320
• Fecha Publicación: 22/05/2012
• Nº Volúmenes: 1
• Idioma: Inglés