This book covers the fundamentals, experimental procedures, and applications of dried blood spot (DBS) sampling in combination with various qualitative and quantitative analytical techniques. This includes sample collection, storage, transportation, and sample preparation for various analysis. Experimental examples in newborn screening, toxicokinetics and pharmacokinetics, and forensics are also given. Finally, the book provides an overview of trends in quantitative and qualitative analysis of DBS samples as well as future perspectives. This provides a valuable working guide to researchers, professionals, and students in healthcare, medical science, diagnosis, chemistry, and pharmaceuticals. INDICE: Preface Wenkui Li, Mike S. Lee Part I History, Applications, and Healthcare 1. Overview of the History and Applications of Dried Blood Samples W. Harry Hannon and Bradford L. Therrell, Jr. 2. Dried Blood Spot Cards Brad Davin and Harry Hannon 3. Dried Blood Spot Sample Collection, Storage and Transportation Joanne Mei 4. Dried Blood Spot Specimen for Polymerase Chain Reaction in Molecular Diagnostics and Public Health Surveillance Chunfu Yang 5. Application of Enzyme Immunoassay Methods Using Dried Blood Spot Specimens Mireille B. Kalou 6. Applications of Dried Blood Spots in Newborn and Metabolic Screening Donald H. Chace, Alan R. Spitzer and Víctor R. De Jesús 7. Dried Blood Spots for Use in HIV–Related Epidemiological Studies in Resource–Limited Settings Sridhar Basavaraju and John P. Pitman 8. Use of Dried Blood Spot Samples in HCV, HBV and Influenza–Related Epidemiological Studies Harleen Gakhar and Mark Holodniy 9. Applications of Dried Blood Spots in General Human Health Studies Eleanor Brindle, Kathleen A O’Connor and Dean A Garrett 10. Applications of Dried Blood Spots in Environmental Population Studies Antonia Calafat and Kayoko Kato, 11. The Use of Dried Blood Spots and Stains in Forensic Science Donald H Chace and Nicholas Lappas Part II Pharmaceutical Applications 12. Pharmaceutical Perspectives of Use of Dried Blood Spots Christopher Evans and Neil Spooner 13. Punching and Extraction Techniques for Dried Blood Spot Sample analysis Philip Wong and Christopher A. James 14. Considerations in development and validation of LC–MS/MS method for quantitative analysis of small molecules in dried blood spot samples Wenkui Li 15. Challenges and Experiences with Dried Blood Spot Technology for Method Development and Validation Chester L Bowen and Christopher A Evans 16. Clinical Implications of Dried Blood Spot Assays for Biotherapeutics Matthew E. Szapacs and Jonathan Kehler 17. Potential Role for Dried Blood Spot Sampling and Bioanalysis in Preclinical Studies Qin Ji and Laura Patrone 18. Use of Dried Blood Spots in Genotyping and Phenotyping of Drug Metabolism Studies Theo de Boer, Izaak den Daas, Jaap Wieling, Johan Wemer, and LingSing Chen 19. Application of Dried Blood Spot Sampling in Clinical Pharmacology Trials and Therapeutic Drug Monitoring Kenneth Kulmatycki, Wenkui Li, Lucy Xu and Venkateswar Jarugula 20. Automation in dried blood spot sample collection, processing and analysis for quantitative bioanalysis in pharmaceutical industry Leimin Fan, Katty Wan, Olga Kavetskaia, Huaiqin Wu 21. Beyond Dried Blood Spots – Application of Dried Matrix Spots Shane Needham Part III New Technologies and Emerging Applications 22. Direct Analysis of Dried Blood Spot Samples Paul Abu–Rabie 23. Paper Spray Ionization for Direct Analysis of Dried Blood Spots Jiangjiang Liu, Nicholas E. Manicke, R. Graham Cooks, Zheng Ouyang 24. Direct Solvent Extraction and Analysis of Biomarkers in Dried Blood Spots Using a Flow–Through Autosampler David S. Millington, Haoyue Zhang, M. Arthur Moseley, J. Will Thompson, and Peter Smith 25. Development of Biomarker Assays for Clinical Diagnostics using a Digital Microfluidics Platform David S. Millington, Ramakrishna Sista, Deeksha Bali, Allen Eckhardt and Vamsee Pamula 26. Applications and chemistry of cellulose papers for dried blood spots Jacquelynn Luckwell, Åke Danielsson, Barry Johnson, Sarah Clegg, Mark Green, Alan Pierce 27. Derivatization techniques in dried blood spot analysis Ann–Sofie ME Ingels, Nele Sadones, Pieter MM De Kesel, Willy E Lambert and Christophe P Stove
- ISBN: 978-1-118-05469-7
- Editorial: Wiley–Blackwell
- Encuadernacion: Cartoné
- Páginas: 392
- Fecha Publicación: 01/08/2014
- Nº Volúmenes: 1
- Idioma: Inglés