Cardiac Regeneration and Repair: Pathology and Therapies

Cardiac Regeneration and Repair, Volume One reviews the pathology of cardiac injury and the latest advances in cell therapy. Chapters in part one explore the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. Part two highlights new approaches to cell therapy for cardiac regeneration, and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function. Chapters in part three move on to highlight novel stem cells for cardiac repair, including human embryonic stem cells and human pluripotent stem cells, and detail their current status and future potential for cardiac therapy. Finally, part four explores gene therapy, and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration. Cardiac Regeneration and Repair, Volume One is complemented by a second volume covering biomaterials and tissue engineering. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials. Explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular functionHighlights new approaches to cell therapy for cardiac regeneration and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac functionExplores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration INDICE: Contributor contact detailsWoodhead Publishing Series in BiomaterialsForewordIntroductionPart I: The pathogenesis of congestive heart failure Chapter 1: Cardiac matrix remodeling and heart failure Abstract:1.1 Introduction1.2 Cardiac matrix remodeling in the development and progression of heart failure (HF) after myocardial infarction (MI)1.3 Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in matrix and cardiac remodeling1.4 Role of inflammation in matrix and cardiac remodeling1.5 Role of monocytes and macrophages in matrix and cardiac remodeling1.6 Extracellular matrix (ECM) and collagen deposition1.7 Treatment strategies and considerations1.8 Future trends1.9 Acknowledgments Chapter 2: Cardiac biomechanics and heart dysfunction Abstract:2.1 Introduction2.2 Measures of cardiac biomechanics2.3 Techniques for assessing the parameters used to quantify cardiac function2.4 Passive versus active cardiac function2.5 Effects of ischemia and infarction on cardiac biomechanics2.6 Conclusion Chapter 3: Modifying matrix remodeling to prevent heart failure Abstract:3.1 Introduction3.2 Clinical progress and remaining issues3.3 Extracellular matrix (ECM) remodeling in the post-myocardial infarction setting3.4 Cells that modify ECM remodeling3.5 Therapeutic options3.6 Future trends3.7 Conclusion3.8 Sources of further information and advice3.9 Acknowledgements Part II: Cell therapy for cardiac regeneration and repair Chapter 4: Optimal cells for cardiac repair and regeneration Abstract:4.1 Introduction4.2 Cell candidates for the repair of ischemic myocardium4.3 Mechanisms of stem cell transplantation for myocardium repair4.4 Overview of the centers for cardiac cell transplantation4.5 Conclusion and future trends4.7 Appendix: abbreviations and acronyms Chapter 5: Cell delivery routes for cardiac stem cell therapy Abstract:5.1 Introduction5.2 Intravenous (IV) injection for cell therapy to the heart5.3 Intramyocardial (IM) injection for cell therapy to the heart5.4 Intracoronary (IC) injection for cell therapy to the heart5.5 Advanced methods for cell therapy to the heart: tissue engineering and the cell-sheet technique5.6 Conclusion and future trends5.7 Acknowledgment Chapter 6: Cell therapy to regenerate the ischemic heart Abstract:6.1 Introduction6.2 Pathology of ischemic damage6.3 Goals and mechanisms of cell therapy to regenerate the ischemic heart6.4 Candidate populations for cell therapy6.5 Variables of cell therapy6.6 Conclusion Chapter 7: Cell therapy for cardiac repair - bench to bedside and back Abstract:7.1 Introduction7.2 Transition of stem cell therapeutics from the bench to the clinic7.3 Skeletal myoblasts7.4 Hematological stem cell (HSC) products7.5 Conclusion Chapter 8: Recent advances in cardiac stem cell therapy to restore left ventricular function Abstract:8.1 Introduction8.2 The disputed existence of cardiac stem cells (CSCs)8.3 Therapeutic application of CSCs to restore ventricular function8.4 Future trends8.5 Conclusion Chapter 9: Monitoring myocardial functional regeneration following cardiac stem cell application Abstract:9.1 Introduction9.2 Conventional functional monitoring modalities following cardiac cell application9.3 Evolving imaging modalities for the assessment of myocardial regeneration9.4 Conclusion and future trends Chapter 10: Feasibility of allogeneic stem cells for heart regeneration Abstract:10.1 Introduction10.2 Characteristics and isolation of mesenchymal stem cells (MSCs)10.3 In vivo studies of allogeneic MSCs10.4 Mechanisms of allogeneic MSC therapy10.5 Future trends10.6 Sources of further information and advice Chapter 11: Bone marrow cells and their role in cardiac repair after myocardial infarction Abstract:11.1 Heart disease in the United States11.2 History of bone marrow stem cells11.3 Stem cell niche in the bone marrow11.4 Delivery of bone marrow stem cells to the heart11.5 Clinical trials of bone marrow stem cell therapy11.6 Limitations of bone marrow stem cell therapy11.7 Conclusion Part III: Stem cells for cardiac regeneration and repair Chapter 12: Cardiac cell therapy to restore contracting elements Abstract:12.1 Introduction12.2 Contractile elements and their importance in normal cardiac function12.3 Evidence that cellular therapies can restore cardiac contractility12.4 Future trends12.5 Sources of further information and advice Chapter 13: Human embryonic stem cells (hESCs) for heart regeneration Abstract:13.1 Introduction13.2 Rationale for using embryonic stem cells (ESCs) to treat severe heart failure13.3 ESCs for severe heart failure: preclinical data13.4 ESCs for severe heart failure: specific translational issues13.5 Issues common to all cell therapy products13.6 Future trends13.7 Conclusion13.8 Sources of further information and advice Chapter 14: Human pluripotent stem cells (hPSCs) for heart regeneration Abstract:14.1 Introduction14.2 Background to cardiovascular disease and cardiac remodeling and repair14.3 Cardiovascular developmental bioengineering14.4 Cardiac disease modeling with human induced pluripotent stem cells14.5 Conclusion Chapter 15: Cardiac cell therapy: current status and future trends Abstract:15.1 Introduction15.2 Current cell delivery methods15.3 Cell types for cardiac regeneration15.4 In vivo cell tracking15.5 Evaluation of heart function15.6 Cardiac cell therapy issues15.7 Future trends Part IV: Gene therapy for cardiac regeneration and repair Chapter 16: Stem cell and gene therapy for cardiac regeneration Abstract:16.1 Introduction16.2 Non-cardiac progenitor cells16.3 Cardiac stem cells (CSCs)16.4 Mechanisms of cardiac regeneration16.5 Mechanisms of cardiac gene transfer16.6 Conclusion and future trends Chapter 17: Ultrasound-targeted cardiovascular gene therapy Abstract:17.1 Introduction17.2 Ultrasound-mediated gene delivery (UMGD)17.3 Microbubble carrier agents17.4 Gene/nucleic acid vectors17.5 Ultrasound and bioeffects17.6 Experimental considerations and protocols17.7 Therapeutic applications of UMGD17.8 Future trends Index

• ISBN: 978-0-08-101576-6
• Editorial: Woodhead Publishing
• Encuadernacion: Rústica
• Páginas: 448
• Fecha Publicación: 30/06/2016
• Nº Volúmenes: 1
• Idioma: Inglés