Cardiac Regeneration and Repair: Biomaterials and Tissue Engineering

Cardiac Regeneration and Repair, Volume Two reviews the use of biomaterials, alone or combined with cell therapy, in providing tissue-engineered constructs to repair the injured heart and prevent or reverse heart failure. Part one explores the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Further chapters explore the use of biomaterials to enhance stem cell therapy for restoring ventricular function and generating stem cell-modified intravascular stents. Part two focuses on tissue engineering for cardiac repair, including chapters on decellularized biologic scaffolds, synthetic scaffolds, cell sheet engineering, maturation of functional cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro applications, and clinical considerations for cardiac tissue engineering. Finally, part three explores vascular remodeling, including chapters highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels. Cardiac Regeneration and Repair, Volume Two is complemented by an initial volume covering pathology and therapies. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials. Surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels.Focuses on tissue engineering for cardiac repair including clinical considerations for cardiac tissue engineeringExplores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels INDICE: Contributor contact detailsWoodhead Publishing Series in BiomaterialsForewordIntroductionPart I: Biomaterials for cardiac regeneration and repair Chapter 1: Nanotechnology and nanomaterials for cardiac repair Abstract:1.1 Introduction1.2 Electrospinning nanofibrous scaffolds1.3 Conductive nanomaterial for myocardial infarction (MI)1.4 Nanomedicine1.5 Future trends Chapter 2: Hydrogels for cardiac repair Abstract:2.1 Introduction2.2 Hydrogels2.3 Injectable hydrogels alone for cardiac repair2.4 Hydrogels as a platform for co-delivery2.5 Delivery strategies of hydrogels2.6 Future trends2.7 Sources of further information and advice Chapter 3: Injectable biomaterials for cardiac regeneration and repair Abstract:3.1 Introduction3.2 Design criteria for biomaterials in cardiac tissue engineering3.3 Injectable biomaterials3.4 Bioactive molecules used in cardiac tissue engineering3.5 Hydrogels to promote endogenous cardiac regeneration and repair3.6 Hydrogels for the delivery of cells for cardiac regeneration3.7 Hydrogels for the artificial maintenance of ventricle geometry and repair3.8 Future trends Chapter 4: Biomaterials for enhancing endothelial progenitor cell (EPC) therapy for cardiac regeneration Abstract:4.1 Introduction4.2 Endothelial progenitor cells (EPCs)4.3 Enhancing EPC therapy4.4 Future trends4.5 Conclusion Chapter 5: Endothelial progenitor cell (EPC)-seeded intravascular stents Abstract:5.1 Intravascular stents5.2 Endothelial progenitor cells (EPCs)5.3 EPC-seeded intravascular stents5.4 Conclusion5.5 Sources of further information and advice Part II: Tissue engineering for cardiac regeneration and repair Chapter 6: Biomaterials and cells for cardiac tissue engineering Abstract:6.1 Introduction6.2 Cardiac structure6.3 Cardiac remodeling in myocardial infarction (MI)6.4 Cells for cardiac tissue engineering6.5 Materials for cardiac tissue engineering6.6 Creation of heart tissue using cell and biomaterials: an in vitro approach6.7 Creation of heart tissue using cell and biomaterials: an in vivo approach of injectable matrices6.8 Vascularization in myocardial tissue engineering6.9 Ventricular aneurysm repair using cells and biomaterials6.10 Clinical applications6.11 Conclusion and future trends Chapter 7: Decellularized biological scaffolds for cardiac repair and regeneration Abstract:7.1 Introduction7.2 Methods of bioscaffold preparation7.3 Cardiac repair with non-cardiac bioscaffolds7.4 Tissue specificity of extracellular matrix bioscaffolds7.5 Current methods for decellularizing cardiac tissue7.6 Whole organ engineering Chapter 8: Biomaterial scaffolds for cardiac regeneration and repair derived from native heart matrix Abstract:8.1 Heart failure and cardiac tissue engineering8.2 Extracellular matrix (ECM) as a biomaterial8.3 Cardiac ECM as a scaffold for cardiac tissue engineering8.4 Hybrid scaffolds for cell delivery into the heart8.5 Native heart ECM hydrogels for cardiac differentiation8.6 Current limitations and future trends8.7 Acknowledgments Chapter 9: Cell sheet engineering for cardiac repair and regeneration Abstract:9.1 Introduction9.2 Skeletal myoblasts9.3 Cardiac progenitor cells and cardiac stem cell sheets9.4 Other tissue stem/progenitor cells and cell sheets9.5 Pulsatile cardiac cell sheet and transplantation into animal models9.6 Cardiac differentiation from human embryonic stem cells (ESCs)/induced pluripotent stem cells (iPSCs)9.7 Engineered cardiac tissue using ESC/iPSC-derived cardiomyocytes9.8 Future trends9.9 Conclusion9.10 Acknowledgements Chapter 10: Maturation of functional cardiac tissue patches Abstract:10.1 Introduction10.2 Native cardiac development10.3 Engineering and functional maturation of biomimetic cardiac tissues10.4 Promoting the maturation of cardiac tissue patches10.5 MicroRNAs10.6 Pluripotent stem cells and their associated molecular effectors10.7 Mechanical forces and stiffness in cardiac tissue engineering10.8 Conclusions and future trends10.9 Acknowledgements Chapter 11: Vascularizing engineered tissues for in vivo and in vitro applications Abstract:11.1 Introduction11.2 Strategies to vascularize engineered tissues11.3 In vitro applications11.4 In vivo applications11.5 Major barriers and future trends11.6 Conclusion Chapter 12: Clinical considerations for cardiac tissue engineering Abstract:12.1 Introduction12.2 Heart muscle engineering concepts and applications12.3 Cell types for clinical translation12.4 Extracellular matrix from within or outside12.5 In vivo studies in large animal models12.6 Clinical translation12.7 Future trends12.8 Sources of further information and advice12.9 Acknowledgements Part III: Vascular remodelling for regeneration and repair Chapter 13: Aortic extra cellular matrix (ECM) remodeling Abstract:13.1 Introduction13.2 The aorta13.3 Pathophysiological changes in thoracic aortic aneurysm (TAA) development13.4 Extracellular matrix (ECM) remodeling13.5 Protease activity13.6 Regulation of protease activity13.7 Challenges and pitfalls of clinical therapy13.8 Conclusion Chapter 14: Cell-biomaterial interactions for blood vessel formation Abstract:14.1 Introduction14.2 Blood vessel architecture14.3 Matrices to investigate vasculogenesis mechanisms14.4 Matrices to direct in vitro prevascularization14.5 Scaffolds to induce and study angiogenesis14.6 Manipulating materials to guide vascular assembly and formation14.7 Future trends14.8 Conclusion Chapter 15: Stem cells in tissue-engineered blood vessels for cardiac repair Abstract:15.1 Introduction15.2 Development of biodegradable tissue-engineered vascular grafts (TEVGs)15.3 Techniques for in vivo experiments and evaluation15.4 Clinical application of TEVGs15.5 Future trends15.6 Sources of further information and advice Chapter 16: Tissue-engineered cardiovascular grafts and novel applications of tissue engineering by self-assembly (TESAT) Abstract:16.1 Introduction16.2 Clinical setting16.3 Current options and the need for alternative conduits16.4 Evolution of cardiovascular tissue engineering16.5 Tissue engineering by self-assembly (TESAT): a scaffold-free technology16.6 Clinical results with TESAT technology16.7 Future trends Index

• ISBN: 978-0-08-101560-5
• Editorial: Woodhead Publishing
• Encuadernacion: Rústica
• Páginas: 528
• Fecha Publicación: 30/06/2016
• Nº Volúmenes: 1
• Idioma: Inglés