Oral bioavailability: basic principles, advanced concepts, and applications
Lee, Mike S.
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
- ISBN: 978-0-470-26099-9
- Editorial: John Wiley & Sons
- Encuadernacion: Rústica
- Páginas: 448
- Fecha Publicación: 22/07/2011
- Nº Volúmenes: 1
- Idioma: Inglés