Silk is increasingly being used as a biomaterial for tissue engineering applications, as well as sutures, due to its unique mechanical and chemical properties. Silk Biomaterials for Tissue Engineering and Regenerative Medicine discusses the properties of silk that make it useful for medical purposes and its applications in this area. Part one introduces silk biomaterials, discussing their fundamentals and how they are processed, and considering different types of silk biomaterials. Part two focuses on the properties and behavior of silk biomaterials and the implications of this for their applications in biomedicine. These chapters focus on topics including biodegradation, bio-response to silk sericin, and capillary growth behavior in porous silk films. Finally, part three discusses the applications of silk biomaterials for tissue engineering, regenerative medicine, and biomedicine, with chapters on the use of silk biomaterials for vertebral, dental, dermal, and cardiac tissue engineering. Silk Biomaterials for Tissue Engineering and Regenerative Medicine is an important resource for materials and tissue engineering scientists, R&D departments in industry and academia, and academics with an interest in the fields of biomaterials and tissue engineering. Discusses the properties and applications of silk for medical purposesConsiders pharmaceutical and cosmeceutical applications INDICE: Contributor contact detailsWoodhead Publishing Series in BiomaterialsForewordPart I: Fundamentals, processing and types of silk biomaterials Chapter 1: Introduction to silk biomaterials Abstract:1.1 Introduction1.2 General information about silkworms1.3 Silk proteins1.4 Genetics of silkworms1.5 Diseases of silkworms1.6 Applications of silks1.7 Application of silk protein fibroins1.8 Application of silk protein sericins1.9 Conclusion1.10 Acknowledgments Chapter 2: Applications of silk biomaterials in tissue engineering and regenerative medicine Abstract:2.1 Introduction2.2 Silk scaffolds in tissue engineering and regenerative medicine2.3 Hard tissue engineering2.4 Soft tissue engineering2.5 Tissue engineering for application in specific organs2.6 Conclusion and future trends2.7 Acknowledgments Chapter 3: Processing of Bombyx mori silk for biomedical applications Abstract:3.1 Introduction3.2 Modulation of silk biomaterial properties3.3 Silk fibroin materials and their use in biomedical applications3.4 Conclusion and future trends Chapter 4: Silk nanostructures based on natural and engineered self-assembly Abstract:4.1 Introduction4.2 Mechanisms of self-assembly in natural and engineered systems4.3 Assembly of natural and recombinant silk proteins4.4 Engineering the self-assembly of silk4.5 Silk nano-architectures and their applications4.6 Self-assembly in conjugation with other (bio)materials4.7 Conjugation with natural and synthetic materials4.8 Conclusion and future trends Chapter 5: Electrospun silk sericin nanofibers for biomedical applications Abstract:5.1 Introduction5.2 Application of silk sericin in the biomedical field5.3 Electrospinning5.4 Silk sericin nanofibers from electrospinning5.5 Molecular structure and physical properties5.6 Silk sericin/silk fibroin blend nanofibers by electrospinning5.7 Conclusion and future trends Chapter 6: Silk fibroin microfiber and nanofiber scaffolds for tissue engineering and regeneration Abstract:6.1 Introduction6.2 Silk fibroin (SF) microfibers for skin and connective tissue regeneration6.3 Formic acid (FA)-cross-linked 3-D SF microfiber-based nonwovens6.4 SF microfiber-based carded-needled 3-D nonwovens6.5 Nanofibers from electrospinning and tissue engineering6.6 Electrospun SF tubes for small calibre blood vessel regeneration Chapter 7: Silk powder for regenerative medicine Abstract:7.1 Introduction7.2 Silk particle production by the bottom up approach7.3 Silk powder production by the top down approach (milling)7.4 Characterisation of silk powder7.5 Applications of silk particles7.6 Conclusion Part II: Properties and behaviour of silk biomaterials Chapter 8: Biochemical and biophysical properties of native Bombyx mori silk for tissue engineering applications Abstract:8.1 Introduction8.2 Genetic sequence and primary structure of silk proteins8.3 Structure and assembly of native silk fibroin8.4 Physical and chemical properties of native silk fibroin fibers8.5 Conclusion Chapter 9: Structure and properties of spider and silkworm silk for tissue scaffolds Abstract:9.1 Introduction9.2 Microstructure of silks9.3 Mechanical properties9.4 Relationship between structure and properties9.5 Biomimetic approaches9.6 Conclusion9.7 Acknowledgments Chapter 10: Types and properties of non-mulberry silk biomaterials for tissue engineering applications Abstract:10.1 Introduction10.2 Classification of silkworms10.3 Life cycle of silkworms10.4 Types of non-mulberry silk10.5 Structure and mechanical properties of silk10.6 Processing of silk proteins10.7 Different formats of silk protein as biomaterials: fibroin10.8 Different formats of silk protein as biomaterials: sericin10.9 Applications of non-mulberry silk protein as biomaterials in biomedicine and biotechnology10.10 Immunological response to silk10.11 Silk degradation10.12 Conclusion and future trends Chapter 11: Bio-response to silk sericin Abstract:11.1 Introduction11.2 Biological responses to biomaterials11.3 Aspects of tissue responses to biomaterials11.4 Evaluation of biological responses to biomaterials11.5 Significant issues in in vivo testing11.6 Reports on biological responses to silk sericin11.7 Investigation of biological responses to silk sericin11.8 Clinical investigation of silk sericin11.9 Conclusion11.10 Acknowledgement Chapter 12: Biodegradation behavior of silk biomaterials Abstract:12.1 Introduction12.2 In vitro biodegradation behavior of silk fibroin materials12.3 In vivo biodegradation behavior and inflammatory responses of silk fibroin materials12.4 Biodegradation behavior of sericin12.5 Conclusion and future trends Chapter 13: Capillary growth behavior in porous silk films Abstract:13.1 Introduction13.2 Growth model of capillaries13.3 Growth process of capillaries13.4 The model of oxygen diffusion of the capillary and capillary density13.5 The construction of capillary systems in biomaterials13.6 Discussion on the oxygen concentration around a capillary13.7 Growth process of capillaries in porous silk fibroin films (PSFFs) implanted into the dermis13.8 Forms of angiogenesis in PSFFs after implantation13.9 Conclusion13.10 Acknowledgment Part III: Tissue engineering, regenerative medicine and biomedical applications of silk biomaterials Chapter 14: Silk biomaterials for intervertebral disk (IVD) tissue engineering Abstract:14.1 Introduction14.2 Suitability of using silk as a biomaterial in tissue engineering14.3 Key factors to be considered before IVD tissue engineering14.4 Tissue engineering approaches to regenerate the hierarchical architecture of IVD14.5 Conclusions Chapter 15: Silk scaffolds for dental tissue engineering Abstract:15.1 Introduction15.2 Clinical challenges in dentistry15.3 From tooth development to repair15.4 Dental tissue engineering15.5 Silk-based biomaterial scaffolds for dental tissue engineering15.6 Conclusion and future trends Chapter 16: Silk for cardiac tissue engineering Abstract:16.1 Introduction16.2 Current therapies and their limitations16.3 Potential strategies to treat heart disease16.4 Specific requirements for cardiac tissue engineering16.5 Silk protein fibroin for cardiac tissue engineering16.6 Conclusion16.7 Acknowledgements Chapter 17: Silk for dermal tissue engineering Abstract:17.1 Introduction17.2 Human skin structure, wound healing and substitute assisted wound healing17.3 Physical properties and processing options of silk fibroin17.4 Dermal tissue engineering using silk fibroin17.5 Silk fibroin films, membranes and coatings17.6 Silk fibroin hydrogels17.7 Silk fibroin porous sponges17.8 Silk fibroin micro-/nano-fibrous scaffolds17.9 Conclusion and future trends Chapter 18: Silk scaffolds for three-dimensional (3D) tumor modeling Abstract:18.1 Introduction18.2 Biological background18.3 Three-dimensional (3D) in vitro tumor modeling: bridging theory and clinical applications18.4 Methods of 3D in vitro tumor modeling18.5 How silk-based tissue engineering applications can help cancer research18.6 Future trends18.7 Conclusion Chapter 19: Silk hydrogels for tissue engineering and dual-drug delivery Abstract:19.1 Introduction19.2 Gelation of silk with ethanol19.3 Mechanical properties and molecular networks19.4 Bound and bulk water contents in silk hydrogel19.5 Cell viability (cytotoxicity)19.6 Silk-based dual-drug delivery system: hydrogels containing nanoparticles19.7 Dual-drug release behavior from silk hydrogel19.8 Conclusion and future trends19.9 Acknowledgment Chapter 20: Silk for pharmaceutical and cosmeceutical applications Abstract:20.1 Introduction20.2 Sources of silk20.3 Properties of silk20.4 Methods of fabrication20.5 Types of formulations20.6 Pharmaceutical applications of silk20.7 Dermatological applications20.8 Conclusion Index
- ISBN: 978-0-08-101388-5
- Editorial: Woodhead Publishing
- Encuadernacion: Rústica
- Páginas: 570
- Fecha Publicación: 30/06/2016
- Nº Volúmenes: 1
- Idioma: Inglés