Pharmacology in Drug Discovery: Understanding Drug Response is designed for all students, recent graduates, and new researchers in the pharmaceutical and biotechnology industries who need to interpret change in physiology induced by a chemical substance. Physiological systems customize chemical signal input totheir own needs; therefore, the same drug can have different effects in different physiological systems. The field of pharmacology is unique in that it furnishes the tools to analyze these different behaviors and traces them to theirroot cause. This enables predictions of drug behavior to be made in all systems, an invaluable tool for drug discovery because almost all drugs are developed in test systems far removed from the therapeutic one. This valuable resource provides simple explanations of the ways in which biological systems use basic biochemical mechanisms to produce fine chemical control of physiology, allowing for more informed predictions of drug effects in all systems and forming the basis of the drug-discovery process. Chapters follow a logical progressionon how to characterize the pharmacology of any given molecule and include important terminology, chapter summaries, references, and review questions to aidthe reader in understanding and retention of the material. Bridges the gap between biochemistry and therapeutic medicineChapters include key topics such asdrug affinity and efficacy, enzymes as drug targets, in vivo pharmacology, safety pharmacology, and moreEnables the reader to interpret drug dose-response data and make mechanistic inferences at the molecular level
- ISBN: 978-0-12-384856-7
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 260
- Fecha Publicación: 31/12/2011
- Nº Volúmenes: 1
- Idioma: Inglés