Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field INDICE: Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors Michael T. Klein, Paige N. Vinson and Colleen M. Niswender Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders Karen J. Gregory, Meredith J. Noetzel and Colleen M. Niswender Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery Magalie Rochville, Julio Martin, Jeffrey Clifford Jerman & Evi Kostenis G Protein-Coupled Receptors in Cancer : Biochemical Interactions and Drug Design Yves Audigier, François-Xavier Picault, Carline Chaves-Almagro and Bernard Masri GPCRs in Stem Cell Function Van A. Doze and Dianne M. Perez Application of Receptor Theory to Allosteric Modulation of Receptors David A. Hall What Ligand-Gated Ion Channels Can Tell Us about the Allosteric Regulation of G protein-Coupled Receptors Frederick J. Ehlert Modelling Cooperativity Effects in Dimeric G Protein-Coupled Receptors Jesús Giraldo Chemokine Receptor Oligomerization and Allostery Bryan Stephens and Tracy M. Handel Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators Peishen Zhao, Wendy Cladman, Hubert HM Van Tol and Peter Chidiac

• ISBN: 978-0-12-394587-7
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 488
• Fecha Publicación: 18/04/2013
• Nº Volúmenes: 1
• Idioma: Inglés