Antiviral drugs: from basic discovery through clinical trials

This book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical development. Organized by a virus (such as HIV, HCV, RSV, influenza, HBV and CMV) and written by top academic and industrial authorities in the field, the book provides a unique opportunity to study, understand and apply discovery and development principles and learning without the need for an individual to research, analyze and synthesize all immense sourcing references. Topics showcase challenges and solutions of issues encountered, offering tremendous experience accumulated over many years of research that will be particularly useful to basic and bench scientists as well as clinicians as they continue discovering and developing new drugs and therapies. INDICE: Part I. Human Immunodeficiency Virus (HIV). Section I. HIV Protease Inhibitors. 1. Atazanavir (Nicholas A. Meanwell, R. Todd Bunch and Awny Farajallah). 2. PL100: A Novel HIV1 Protease Inhibitor (Jinzi J. Wu and Joseph Musto). 3. Darunavir (PREZISTA, TMC114): from bench to clinic, improving treatment options for HIVinfected patients (MariePierre de Béthune, Vanitha Sekar, Sabrina SpinosaGuzman, Marc Vanstockem, Sandra De Meyer, Piet Wigerinci ad Eric Lefebvre). 4. Discovery and Development o Tipranavir (Karen R. Romines). Section II. HIV NonNucleoside Reverse Transcriptase Inhibitors. 5. TMC278 (rilpivirine): a nextgeneration NNRTI in Phase III clinical development for treatmentnaïve patients (Jérôme Guillemont, Herta Crauwels, Katia Boven and MariePierre deBéthune). 6. Etravirine: from TMC125 to INTELENCE a treatment paradigm shift for HIVinfected patients (Koen Andries, Ann Debunne, Thomas N. Kakuda, MichaelKukla, Ruud Leemans, Johan Vingerhoets, Brian Woodfall and MariePierre de Béthune). Section III. Nucleoside Reverse Transcriptase Inhibitors. 7. Tenofovir Disoproxil Fumarate (Tdf): Discovery and Clinical Development (Erik De Clercq). 8. Discovery and Clinical Development of Apricitabine (Susan Cox, John Deadman, Justine Southby and Jonathan Coates). Section IV. HIV Entry Inhibitors. 9.Discovery and Development of Maraviroc and PF232798: CCR5 Antagonists for thetreatment of HIV1 infection (Patrick Dorr and Paul Stupple). 10. Discovering of the CCR5 Antagonist Vicriviroc (SCH 417690/SCHD) For Treatment of HIV1 Infection (Jayaram R. Tagat, Julie M. Strizki, and Lisa M. Dunkle). 11. Discovery and Development of HIV1 Entry Inhibitors That Target gp120 (John F. Kadow, John Bender, Alicia RegueiroRen, Yasutsugu Ueda, Tao Wang, KapSun Yeung and Nicholas A. Meanwell). Section V. HIV Integrase Inhibitors. 12. Discovery of MK0536: A Potential Second Generation HIV1 Integrase Strand Transfer Inhibitor with a High Genetic Barrier to Mutation (Melissa S. Egbertson, John S. Wai, Mark Cameron and R. Scott Hoerrner). 13. Discovery and Development of HIV Integrase Inhibitor Realegravir (Vincenzo Summa and Paola Pace). 14. Elvitegravir, A Novel Mono keto Acid HIV1 Integrase Strand Transfer Inhibitor (Hisashi Shinkai, Masanori Sato and Yuji Matsuzaki). Part II. Hepatitis C Virus (HCV). Section VI. HCV Protease Inhibitors. 15. Telaprevir (AnneLaure Grillot, Luc J. Farmer, B. Govinda Rao, William P. Taylor, Iian S. Weisberg, Ira M. Jacobson, Robert B.Perni and Ann D. Kwong). 16. Discovery and Development of BILN 2061 and Followup Bl 201335 (MontseLlinàsBrunet and Peter W. White). 17. Intervention of Hepatitis C Replication through NS34A Protease Inhibitor, Boceprevir (Srikanth Venkatraman and F. George Njoroge). 18. Discovery 6130. RG7128 (Phillip A. Furman, Michael J. Otto, and Michael J. Sofia). Section VIII. Other HCV Inhibitors.22. Discovering of cyclophilin inhibitor NIM811 as a novel therapeutic agent for HCV (Kai Lin). 23. HCV viral entry inhibi

• ISBN: 978-0-470-45563-0
• Editorial: John Wiley & Sons
• Encuadernacion: Cartoné
• Páginas: 488
• Fecha Publicación: 01/07/2011
• Nº Volúmenes: 1
• Idioma: Inglés