Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology—from immunity and inflammation to apoptosis, cell survival, growth, and proliferation NF-kappaB transcription factors regulate a number of important physiological processes, including inflammation and immune responses, cell growth and survival, and the expression of certain viral genes Moreover, NF-kappaB activity is elevated in andcontributes to the pathology of several human diseases, including many cancers and chronic inflammatory diseases INDICE: Preface.- Understanding the Logic of IkappaB:NF-kappaB Regulation in Structural Terms.- IKK regulation and human genetics.- Specialized chromatin patterns in the control of inflammatory gene expression.- Macrophages and NF-kappaB in Cancer.- NF-?B/Rel proteins and the humoral immune responses of Drosophila melanogaster.- IKK and NF-kappaB mediated functions in carcinogenesis.- Control of NF-kappaB activity by proteolysis.- NF-kappaB as a target for oncogenic viruses.- NF-kappaB and Innate Immunity.- Inhibition of NF-kappaB signaling as a strategy in disease therapy.- NF-?B and mucosal homeostasis.- NF-kappaB In liver cancer – the plot thickens.- Subject index.
- ISBN: 978-3-642-16016-5
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 280
- Fecha Publicación: 15/12/2010
- Nº Volúmenes: 1
- Idioma: Inglés