Trypanosomatid Diseases: Molecular Routes to Drug Discovery

This is the first resource to provide researchers in academia and industry with an urgently needed update summarizing the current knowledge and possibilities for drug intervention against Trypanosomatides all in one volume. As such, it covers every aspect of the topic from basic research findings, via current treatments to translational approaches in drug development and includes both human and livestock diseases. The outstanding editor and contributor team reads like a Who?s Who of the field, thus guaranteeing the outstanding quality of this ready reference. INDICE: Foreword IX Acknowledgment XV Preface XVII List of Contributors XIX Part One Disease Burden, Current Treatments, Medical Needs, and Strategic Approaches 1 1 Visceral Leishmaniasis – Current Treatments and Needs 3 Poonam Salotra, Ruchi Singh, and Karin Seifert 2 Chemotherapy of Leishmaniasis: A Veterinary Perspective 17 María Jesus Corral–Caridad and Jose María Alunda 3 Pharmacological Metabolomics in Trypanosomes 37 Darren J. Creek, Isabel M. Vincent, and Michael P. Barrett 4 Drug Design and Screening by In Silico Approaches 57 Mattia Mori and Maurizio Botta 5 Computational Approaches and Collaborative Drug Discovery for Trypanosomal Diseases 81 Sean Ekins and Barry A. Bunin Part Two Metabolic Peculiarities in the Trypanosomatid Family Guiding Drug Discovery 103 6 Interaction of Leishmania Parasites with Host Cells and its Functional Consequences 105 Uta Schurigt, Anita Masic, and Heidrun Moll 7 Function of Glycosomes in the Metabolism of Trypanosomatid Parasites and the Promise of Glycosomal Proteins as Drug Targets 121 Melisa Gualdron–Lopez, Paul A.M. Michels, Wilfredo Qui?nones, Ana J. Caceres, Luisana Avilan, and Juan–Luis Concepcion 8 Glyoxalase Enzymes in Trypanosomatids 153 Marta Sousa Silva, Antonio E.N. Ferreira, Ricardo Gomes, Ana M. Tomas, Ana Ponces Freire, and Carlos Cordeiro 9 Trypanothione–Based Redox Metabolism of Trypanosomatids 167 Marcelo A. Comini and Leopold Flohe 10 Thiol Peroxidases of Trypanosomatids 201 Helena Castro and Ana M. Tomas 11 Peroxynitrite as a Cytotoxic Effector Against Trypanosoma cruzi: Oxidative Killing and Antioxidant Resistance Mechanisms 215 Madia Trujillo, María Noel Alvarez, Lucía Piacenza, Martín Hugo, Gonzalo Peluffo, and Rafael Radi 12 Selenoproteome of Kinetoplastids 237 Alexei V. Lobanov and Vadim N. Gladyshev 13 Replication Machinery of Kinetoplast DNA 243 Rachel Bezalel–Buch, Nurit Yaffe, and Joseph Shlomai 14 Life and Death of Trypanosoma brucei: New Perspectives for DrugDevelopment 261 Torsten Barth, Jasmin Stein, Stefan Mogk, Caroline Sch€onfeld, Bruno K. Kubata, and Michael Duszenko Part Three Validation and Selection of Drug Targets in Kinetoplasts 279 15 Rational Selection of Anti–Microbial Drug Targets: Unique or Conserved? 281 Boris Rodenko and Harry P. de Koning 16 Drug Targets in Trypanosomal and Leishmanial Pentose Phosphate Pathway 297 Marcelo A. Comini, Cecilia Ortíz, and Juan Jose Cazzulo 17 GDP–Mannose: A Key Point for Target Identification and Drug Design in Kinetoplastids 315 Sebastien Pomel and Philippe M. Loiseau 18 Transporters in Anti–Parasitic Drug Development and Resistance 335 Vincent Delespaux and Harry P. de Koning 19 Peptidases in Autophagy are Therapeutic Targets for Leishmaniasis 351 Roderick A.M. Williams 20 Proteases of Trypanosoma brucei 365 Dietmar Steverding Part Four Examples of Target–Based Approaches and Compounds Under Consideration 383 21 Screening Approaches Towards Trypanothione Reductase 385 Mathias Beig, Frank Oellien, R. Luise Krauth–Siegel, and Paul M. Selzer 22 Redox–Active Agents in Reactions Involving the Trypanothione/Trypanothione Reductase–based System to Fight Kinetoplastidal Parasites 405 Thibault Gendron, Don Antoine Lanfranchi, and Elisabeth Davioud–Charvet 23 Inhibition of Trypanothione Synthetase as a Therapeutic Concept 429 Oliver Koch, Timo J€ager, Leopold Flohe, and Paul M. Selzer 24 Targeting the Trypanosomatidic Enzymes Pteridine Reductase and Dihydrofolate Reductase 445 Stefania Ferrari, Valeria Losasso, Puneet Saxena, and Maria Paola Costi 25 Contribution to New Therapies for Chagas Disease 473 Patricia S. Doyle and Juan C. Engel 26 Ergosterol Biosynthesis for the Specific Treatment of Chagas Disease: From Basic Science to Clinical Trials 489 Julio A. Urbina 27 New Developments in the Treatment of Late–Stage Human African Trypanosomiasis 515 Cyrus J. Bacchi, Robert T. Jacobs, and Nigel Yarlett Index 531

• ISBN: 978-3-527-33255-7
• Editorial: Wiley VCH
• Encuadernacion: Cartoné
• Páginas: 576
• Fecha Publicación: 17/04/2013
• Nº Volúmenes: 1
• Idioma: Inglés