Nanotechnology Applications for Cancer Chemotherapy

Nanotechnology Applications for Cancer Chemotherapy offers a concise summary of nanotechnological interventions in cancer management. It highlights the basics of oncology, the cancer microenvironment, targets for active drug delivery, and the underlying mechanisms and molecular pathways to enhance drug delivery. The book discusses the principles of basic and innovative nanocarrier-based therapeutic approaches to modulate the progression of disease, however it is not limited to targeted drug delivery for various cancers, as it also explores advancements in cancer imaging and diagnostics employing nanotechnologies. Emphasis lies in techniques like in-vitro cell culture and in-vivo animal models to assess the performance of cancer nanomedicines. The book includes clinical study reports of various drug moieties explored using a variety of nanoconstructs in myriad cancer conditions. Discusses how organic and inorganic nanoplatforms are being used in cancer treatmentShows how nanotechnology is being used to create new and more accurate diagnostic toolsSurveys the current generation of cancer nanomedicines, assessing their advantages and challenges INDICE: 1. Basic pathology and etiology of tumor and its microenvironmen 2. EPR effect and its implication in passive targeting of nanocarrier to the tumor 3. pH sensitive carriers as delivery to tumor 4. Temperature sensitive carrier temperature directed tumor cell eradication 5. Magnetically responsive delivery into tumor environment 6. Ligands used for tumor targeting 7. Therapy targeting angiogenic potential of tumor 8. Immunotherapy of cancer 9. Chemical linkers: Potential approach to target tumor 10. Cell penetrating peptide in cancer targeting 11. Inorganic nanoparticles: A new avenue in improving diagnostic 12. Development of photodynamic cancer therapy 13. Cancer vaccine: Current development 14. Therapeutic based on small interfering RNAs (siRNA) 15. Aptamer conjugates: A new avenue 16. Application of cancer stem cells in improving therapeutics 17. Targeting breast cancer 18. Lung cancer: Improving efficacy and reducing side effects 19. Colorectal cancer: Local targeting 20. Hepatic cancer targeting 21. Solid tumor: Addressing the problems associatedPancreatic cancer: Removing extracellular matrix barrier in delivery 22. Targeting to the CNS: Approach for brain tumor 23. Metastatic cancer: How one can address the therapeutic challenge 24. Prostate cancer: Delivery aspect and prospect 25. Leukemia: Trends in treatment and how close we have achieved eradication 26. Tumor imaging and its application in tumor targeted drug delivery 27. 2D and 3D cell culture: Getting close to mimicking tumor microenvironment in vitro 28. In vivo animal model for cancer: what have we learnt from chemical induced and xenograft models 29. Nanosystem: Regulatory aspects, clinical development and market potential

• ISBN: 978-0-12-817846-1
• Editorial: Elsevier
• Encuadernacion: Rústica
• Páginas: 400
• Fecha Publicación: 01/09/2020
• Nº Volúmenes: 1
• Idioma: Inglés