Cryptic Enzymes and Moonlighting, a new volume in the Foundations and Frontiers in Enzymology series, offers a thorough overview of cryptic enzymes and moonlighting proteins in signaling cascades. It explores recent advances in research and brings together an array of information across different fields to enable better targeting of these exciting proteins and their interactomes. With a clear focus on the role of moonlighting and cryptic enzymes in signal transduction, the book considers examples of cryptic enzymes across species, as well as in human healthy biology and pathogenesis. In early chapters, leading international contributors discuss evolutionary considerations for moonlighting proteins, moonlighting interactions in the extracellular matrix, eukaryotic moonlighting proteins, modulating, moonlighting kinases, moonlighting proteins in neurobiology signaling, metabolic enzymes moonlighting as RNA binding and regulatory proteins. Later, methods-driven chapters discuss practical aspects of identifying hidden moonlighting domains in proteins, computational approaches and bioinformatic tools for the identification of cryptic enzymes, establishing cryptic enzyme interactomes, and assessing contributions of moonlighting proteins to signal cascades. . Covers recent advances in our understanding of cryptic moonlighting proteins in signal cascades, highlighting and examining key themes across disciplines. Empowers researchers to better target cryptic enzymes and moonlighting proteins and their interactomes.. Features chapter contributions from international leaders in the field INDICE: 1. Introduction and overview of moonlighting enzymes in signal cascades2. Evolutionary considerations for moonlighting proteins in signalling cascades3. Moonlighting interactions in the extracellular matrix4. Eukaryotic moonlighting proteins that assist microbial infections5. Modulating immune responses - the role of moonlighting proteins6. Moonlighting kinases7. Moonlighting proteins in neurobiology signalling mediated by G protein coupled receptors (GPCRs)8. Metabolic enzymes co-opted in oncogenic signalling9. Metabolic enzymes moonlighting as RNA binding and regulatory proteins10. Cryptic enzymes as fine tuners of signalling cascades11. Dual function plant cryptic nucleotide cyclases12. Crypto ACs coming of age13. Crypto ACs moonlighting with PDEs in complex proteins14. Gas sensing H-NOX hemo proteins in plants15. Modulating the immune response via cryptic enzymes16. Cryptic moonlighting enzymes enable crosstalk with other signalling molecules17. Identifying hidden moonlighting domains in proteins18. Computational approaches and bioinformatic tools for the identification of cryptic enzymes19. Cryptic enzymes operating in crop plants20. Establishing cryptic enzyme interactomes21. Assessing contributions of moonlighting proteins to signal cascades22. Protein interactomes uncovering moonlighting proteins
- ISBN: 978-0-443-15719-6
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 472
- Fecha Publicación: 15/02/2025
- Nº Volúmenes: 1
- Idioma: Inglés