INDICE: 1. Introduction – a brief history of Hh 2. The Hh signaling pathway in Drosophila 3. The evolution of the Hh pathway 4. Production distribution and reception of the HH ligand 5. The Primary Cilium in HH signalling 6. Mechanisms of Hh signaling in mouse 7. Mechanisms of Hh signaling in zebrafish 8. Hh signaling in neural tube patterning in vertebrates 9. Hh signaling in limb development 10. Hh signaling in endodermal organs 11. Hh signaling in myogenesis 12. Hh signaling in skin biology 13. Hh signaling in bone biology 14. Hh signaling in blood and vascular biology 15. Physiological roles of HH 16. Hh signaling in regeneration 17. Hh and human congenital disorders 18. Hh in regenerative medicine 19. Hh in tumorigenesis 1 20. Hh in tumorigenesis 2 21. Hh in tumorigenesis 3 22. Hh therapeutics Authors: P Ingham (IMCB, Singapore) M Scott (Stanford) P Beachy (Stanford) P Therond (CNRS, Nice) A McMahon (Harvard/USC) J Briscoe (Mill Hill) M. Placzek (U Sheffield) C. Tabin (Harvard Med School) C. Tickle (U Bath) D. Gummucio (U Michigan) A–G Borycki (U Sheffield) A Vortkamp (U Duisberg–Essen) S Eaton (MPI Dresden) K Anderson (MSK) J Reiter (UCSF) R Toftgard (Karolinska) N Lawson (U Mass) T Crompton (ICH, London) P. Beales (ICH, London) Y Sasai (Riken, Kobe) T Curran (U Penn) A Oro (Stanford) F de Sauvage (Genentech, San Francisco)
- ISBN: 978-1-118-52483-1
- Editorial: Wiley–Blackwell
- Encuadernacion: Cartoné
- Páginas: 400
- Fecha Publicación: 29/07/2014
- Nº Volúmenes: 1
- Idioma: Inglés