Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. Although many of the molecular/genetic signalling pathways underlying many disorders are well studied biochemically, how the relevant cellular organization integrates with various signalling molecules is often less clear. This book addresses these ideas, providing a basic resource for understanding the biology of polarity and offering a starting point for those thinking of targeting cell polarity for translational medical research. Provides basic science understanding of cell polarity disease and developmentCovers diseases affecting polarized epithelial tissues in the lung and kidney, and in the progression of cancerIncludes historical context of cell polarity research for potential future breakthroughs INDICE: I) Editor's preface/foreword1. Overview of cell polarity: insights from model organisms and cellular systems2. Cell polarity in the egg and early embyro- mammal3. Pluripotency and cell polarity4. The role of cell polarity in adult stem cell maintenance5. Integration of cell polarity and growth factor signaling6. Cell polarity and the onset and progression of cancer7. Cell division and cell polarity8. Polarized membrane/vesicle trafficking and disease9. Polarized microtubule transport and disease10. Regulation of cell polarity in cell/neuronal migration11. Apical and planar cell polarity in ciliated epithelia12. Renal epithelial cell polarity and disease13. Hepatic cell polarity and disease14. Epidermal cell polarity and disease15. Cell polarity and sensory cell defects
- ISBN: 978-0-12-802438-6
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 336
- Fecha Publicación: 01/06/2017
- Nº Volúmenes: 1
- Idioma: Inglés