Therapeutic resistance to anti-hormonal drugs in breast cancer: new molecular aspects and their potential as targets

One of the main causes of failure in the treatment of breast cancer is the intrinsic presence of, or development of, drug resistance by the cancer cells. Recent studies on the mechanisms of cancer drug resistance have yielded important information highlighting both how tumour cells may escape these therapeuticconstraints and that drug resistance may further impinge on tumour cell functions that may ultimately promote an adverse cell phenotype. New targets have been identified with potential therapeutic applications in resistant breast cancer leading to the subsequent evaluation of inhibitors of these targets in preclinical studies. Importantly, there is increasing evidence from such studies demonstrating the benefit of novel combination strategies as potential avenuesfor future drug regimens. Presents a clear and in-depth overview of both the clinical and scientific aspects of endocrine resistance in breast cancer Includes emerging and novel themes in breast cancer resistance development Reports up-to-date scientific and translational advances in this field INDICE: Part 1: Overview. 1.1 Endocrine resistance in clinical breast cancer. 1.2 Endocrine resistance in experimental breast cancer. Part 2: New Themesin Endocrine Resistance. 2.1 Co-activators / co-repressors and endocrine resistance. 2.2 Antihormone-induced gene changes: consequences for the developmentof drug-resistance. 2.3 Altered signal transduction pathways: impact on ER signalling and expression. 2.4 Epigenetic alterations in DNA methylation in breast cancer. 2.5 Antihormone-induced tumour progression. 2.6 Influence of the tumour microenvironment.2.7 Stem cells. Part 3: New Advances And Innovative Therapeutic Approaches. 3.1 DNA profiling. 3.2 Synthetic lethal approaches to target gene discovery. 3.3 Intelligent combination therapies. 3.4 Novel targeting approaches. 3.5 Future treatment of endocrine-resistant breast cancer: how basic science can guide clinical development.

• ISBN: 978-1-4020-8525-3
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 220
• Fecha Publicación: 01/02/2009
• Nº Volúmenes: 1
• Idioma: Inglés