Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine

Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine, Second Edition transports readers from Mendelian genetics to 4D genomics, building a case for genes and genomes as distinct biological entities where the genome, rather than individual genes, defines system-level inheritance and represents a clear unit of selection for macroevolution. In this thought-provoking text, Dr. Henry Heng invigorates fresh discussions in Genome Architecture Theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine.In this timely new edition, Dr. Heng fully embraces the integration of system information with genome-mediated evolutionary mechanisms, and supports this framework with recent findings and growing, interdisciplinary research. Ten evidence-based chapters discuss 4D genomics, genes and genomes as distinct biological entities, genome chaos and cellular macroevolution, karyotype coding and fuzzy inheritance, as well as an entirely novel model of evolution driven by information flow, and more. Brand-new chapters consider the creation and maintenance of system information for complexity and biodiversity, as well as modes of analyzing information-based and historically contingent evolutionary framework. This synthesis offers a revolutionary paradigm of evolutionary theory. It also hypothesizes about how information flow, matter arrangement, and energy interact. Bridges basic research and clinical applications, providing a foundation for re-examining the results of large-scale -omics studies and precision medicineGathers the most pressing questions in genomics, cytogenomics, and evolutionProposes a novel genome and information-based evolutionary theory that unites the study of physical, chemical, and biological mechanisms within organismal systemsContains ten evidence-based chapters that discuss karyotype coding, function of sex, natural information self-creation, and evolution as platform for both innovation and conservation INDICE: 1. From Mendelian Genetics to 4D Genomics2. Genes and Genomes Represent Different Biological Entities3. Genome Chaos and Cellular Macroevolution: How Evolutionary Cytogenetics Unravels the Mystery of Cancer.4. Karyotype Coding and Fuzzy Inheritance: The Genomic Basis of Bio-information and Heterogeneity5. Why Sex? Genome Reinterpretation Dethrones the Queen6. Breaking the Genome Constraint: The Mechanism of Macroevolution7. The Creation and Maintenance of System Information for Complexity and Biodiversity8. Searching for an Information-Based and Historically Contingent Evolutionary Theory9. The Genome Architecture Theory: A New Framework10. The Rationale and Challenges for Molecular Medicine

• ISBN: 978-0-443-15428-7
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 580
• Fecha Publicación: 01/03/2025
• Nº Volúmenes: 1
• Idioma: Inglés