Handbook of adaptive designs in pharmaceutical and clinical development

This handbook provides a comprehensive and unified presentation of the principles and latest statistical methodologies used when modifying trial proceduresbased on accrued data of ongoing clinical trials. The book also gives a well-balanced summary of current regulatory perspectives and presents real-world examples of a range of adaptive designs. Leading clinical researchers in the pharmaceutical industry, academia, and regulatory agencies examine issues commonly encountered when applying adaptive design methods in clinical trials. They discuss the importance of sample size estimation/allocation, justification, andadjustment when implementing a complicated adaptive design.

• ISBN: 978-1-4398-1016-3
• Editorial: CRC Press
• Encuadernacion: Cartoné
• Páginas: 496
• Fecha Publicación: 27/10/2010
• Nº Volúmenes: 1
• Idioma: Inglés